130299 20240130142253.0 doi 10.1016/j.applanim.2010.01.009 sideral 72158 ART-2010-72158 eng Rosado, B. Universidad de Zaragoza (orcid)0000-0003-1728-900X Blood concentrations of serotonin, cortisol and dehydroepiandrosterone in aggressive dogs 2010 Access copy available to the general public Unrestricted Canine aggression directed towards people is the most frequent reason for referral to behaviour practices. In order to provide new and improved diagnostic and therapeutic approaches for this problem, it is necessary to make an in-depth investigation of the biological basis of aggression in this species. The serotonergic system and the hypothalamic–pituitary–adrenal (HPA) axis are believed to play an important role in controlling aggression. The aim of the present study was to investigate both systems in aggressive (n = 80) and control non-aggressive (n = 19) dogs through the assessment of peripheral parameters, namely serum serotonin (5-HT), and plasma cortisol and dehydroepiandrosterone (DHEA). Moreover, the effect of the category of aggression and gender was investigated. Aggressive dogs showed significantly lower serum concentrations of 5-HT than non-aggressive dogs (278.5 ng/ml vs. 387.4 ng/ml, P < 0.01). The lowest 5-HT concentrations were found in the group of dogs showing defensive forms of aggression. Aggressive animals showed significantly higher plasma concentrations of cortisol than non-aggressive dogs (21.4 ng/ml vs. 10.6 ng/ml, P = 0.05). Finally, males as a whole showed significantly higher plasma concentrations of DHEA and DHEA/cortisol ratio values than did females (DHEA: 90.9 ng/ml vs. 29.8 ng/ml, P < 0.05; ratio: 9.5 vs. 3.8, P < 0.01). The present results suggest that aggressive dogs might differ from non-aggressive dogs in the activities of the serotonergic system and the HPA axis. info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 1.555 2010 AGRICULTURE, DAIRY & ANIMAL SCIENCE 13 / 55 = 0.236 2010 Q1 T1 VETERINARY SCIENCES 29 / 144 = 0.201 2010 Q1 T1 BEHAVIORAL SCIENCES 38 / 48 = 0.792 2010 Q4 T3 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion García-Belenguer, S. Universidad de Zaragoza (orcid)0000-0001-5084-6555 León, M. Chacón, G. Villegas, A. (orcid)0000-0001-8398-5463 Palacio, J. Universidad de Zaragoza (orcid)0000-0002-1581-3085 1001 X Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Proy. investigación DDA 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 123, 3-4 (2010), 124-130 Appl. anim. behav. sci. Applied Animal Behaviour Science 0168-1591 236371 http://zaguan.unizar.es/record/130299/files/texto_completo.pdf Postprint 795169 http://zaguan.unizar.es/record/130299/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:130299 articulos driver 2024-01-30-14:18:26 ARTICLE