000130347 001__ 130347
000130347 005__ 20240124152851.0
000130347 0247_ $$2doi$$a10.1371/journal.pone.0255524
000130347 0248_ $$2sideral$$a136410
000130347 037__ $$aART-2021-136410
000130347 041__ $$aeng
000130347 100__ $$aSuárez-García I
000130347 245__ $$aIn-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain
000130347 260__ $$c2021
000130347 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130347 5203_ $$aBackground
Whether immunosuppressed (IS) patients have a worse prognosis of COVID-19 compared to non-IS patients is not known. The aim of this study was to evaluate the clinical characteristics and outcome of IS patients hospitalized with COVID-19 compared to non-IS patients.
Methods
We designed a retrospective cohort study. We included all patients hospitalized with laboratory-confirmed COVID-19 from the SEMI-COVID-19 Registry, a large multicentre national cohort in Spain, from March 27th until June 19th, 2020. We used multivariable logistic regression to assess the adjusted odds ratios (aOR) of in-hospital death among IS compared to non-IS patients.
Results
Among 13 206 included patients, 2 111 (16.0%) were IS. A total of 166 (1.3%) patients had solid organ (SO) transplant, 1081 (8.2%) had SO neoplasia, 332 (2.5%) had hematologic neoplasia, and 570 (4.3%), 183 (1.4%) and 394 (3.0%) were receiving systemic steroids, biological treatments, and immunosuppressors, respectively. Compared to non-IS patients, the aOR (95% CI) for in-hospital death was 1.60 (1.43–1.79) for all IS patients, 1.39 (1.18–1.63) for patients with SO cancer, 2.31 (1.76–3.03) for patients with haematological cancer and 3.12 (2.23–4.36) for patients with SO transplant. The aOR (95% CI) for death for patients who were receiving systemic steroids, biological treatments and immunosuppressors compared to non-IS patients were 2.16 (1.80–2.61), 1.97 (1.33–2.91) and 2.06 (1.64–2.60), respectively. IS patients had a higher odds than non-IS patients of in-hospital acute respiratory distress syndrome, heart failure, myocarditis, thromboembolic disease and multiorgan failure.
Conclusions
IS patients hospitalized with COVID-19 have a higher odds of in-hospital complications and death compared to non-IS patients.
000130347 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000130347 590__ $$a3.752$$b2021
000130347 591__ $$aMULTIDISCIPLINARY SCIENCES$$b29 / 74 = 0.392$$c2021$$dQ2$$eT2
000130347 592__ $$a0.852$$b2021
000130347 593__ $$aMultidisciplinary$$c2021$$dQ1
000130347 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130347 700__ $$aPerales-Fraile I
000130347 700__ $$aGonzález-García A
000130347 700__ $$aMuñoz-Blanco A
000130347 700__ $$aManzano L
000130347 700__ $$aFabregate M
000130347 700__ $$0(orcid)0000-0002-3132-2171$$aDiez-Manglano J$$uUniversidad de Zaragoza
000130347 700__ $$aAizpuru EF
000130347 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000130347 773__ $$g16 (2021)$$pPLoS One$$tPLoS ONE$$x1932-6203
000130347 8564_ $$s542526$$uhttps://zaguan.unizar.es/record/130347/files/texto_completo.pdf$$yVersión publicada
000130347 8564_ $$s2371453$$uhttps://zaguan.unizar.es/record/130347/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130347 909CO $$ooai:zaguan.unizar.es:130347$$particulos$$pdriver
000130347 951__ $$a2024-01-24-15:04:44
000130347 980__ $$aARTICLE