000130353 001__ 130353 000130353 005__ 20240124152851.0 000130353 0247_ $$2doi$$a10.1136/vr.140.18.477 000130353 0248_ $$2sideral$$a101188 000130353 037__ $$aART-1997-101188 000130353 041__ $$aeng 000130353 100__ $$0(orcid)0000-0002-1581-3085$$aPalacio J. 000130353 245__ $$aEnzymuria as an index of renal damage in canine leishmaniasis 000130353 260__ $$c1997 000130353 5203_ $$aUrinary enzyme activities of alanine aminopeptidase, gammaglutamyl transpeptidase, alkaline phosphatase, N-acetyl-β-D-glucosaminidase and β-glucuronidase were determined in 15 dogs with leishmaniasis and in a group of eight normal dogs. Serum creatinine and blood urea nitrogen concentrations were also measured and renal histology was examined. All the affected dogs had renal lesions. However, no significant differences in blood urea nitrogen and creatinine concentrations were found between the control group and the affected group. The urinary enzyme activities of gamma-glutamyl transpeptidase (P<0.01), N-acetyl-β-D-glucosaminidase (P<0.01) and β-glucuronidase (P<0.05) were significantly higher in the affected dogs. Urinary enzymes therefore seem to be a more sensitive and reliable test for assessing early renal damage in canine leishmaniasis than serum creatinine or blood urea nitrogen concentrations. 000130353 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000130353 590__ $$a1.081$$b1997 000130353 591__ $$aVETERINARY SCIENCES$$b14 / 102 = 0.137$$c1997$$dQ1$$eT1 000130353 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000130353 700__ $$aListe F. 000130353 700__ $$0(orcid)0000-0002-5927-073X$$aGascon M.$$uUniversidad de Zaragoza 000130353 7102_ $$11009$$2665$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cArea Patología Animal 000130353 773__ $$g140, 18 (1997), 477-480$$pVet. rec.$$tVeterinary Record$$x0042-4900 000130353 8564_ $$s1047257$$uhttps://zaguan.unizar.es/record/130353/files/texto_completo.pdf$$yVersión publicada 000130353 8564_ $$s3438997$$uhttps://zaguan.unizar.es/record/130353/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000130353 909CO $$ooai:zaguan.unizar.es:130353$$particulos$$pdriver 000130353 951__ $$a2024-01-24-15:05:00 000130353 980__ $$aARTICLE