000130406 001__ 130406
000130406 005__ 20240125162930.0
000130406 0247_ $$2doi$$a10.1186/cc13956
000130406 0248_ $$2sideral$$a98813
000130406 037__ $$aART-2014-98813
000130406 041__ $$aeng
000130406 100__ $$aLorente, L.
000130406 245__ $$aHigher platelet cytochrome oxidase specific activity in surviving than in non-surviving septic patients
000130406 260__ $$c2014
000130406 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130406 5203_ $$aIntroduction: In a previous study with 96 septic patients, we found that circulating platelets in 6-months surviving septic patients showed higher activity and quantity of cytochrome c oxidase (COX) normalized by citrate synthase (CS) activity at moment of severe sepsis diagnosis than non-surviving septic patients. The objective of this study was to estimate whether COX specific activity during the first week predicts 1-month sepsis survival in a larger cohort of patients.Methods: Using a prospective, multicenter, observational study carried out in six Spanish intensive care units with 198 severe septic patients, we determined COX activity per proteins (COXact/Prot) in circulating platelets at day 1, 4 and 8 of the severe sepsis diagnosis. Endpoints were 1-month and 6-months mortality.Results: Survivor patients (n = 130) showed higher COXact/Prot (P 0.30 mOD/min/mg at day 1 (P = 0.002), 4 (P = 0.006) and 8 (P = 0.02) was associated independently with 1-month mortality. Area under the curve of COXact/Prot at day 1, 4 and 8 to predict 30-day survival were 0.70 (95% CI = 0.63-0.76; P < 0.001), 0.71 (95% CI = 0.64-0.77; P < 0.001) and 0.71 (95% CI = 0.64-0.78; P < 0.001), respectively.Conclusions: The new findings of our study, to our knowledge the largest series reporting data about mitochondrial function during follow-up in septic patients, were that septic patients that survive 1-month have a higher platelet cytochrome oxidase activity at moment of sepsis diagnosis and during the first week than non-survivors, and that platelet cytochrome oxidase activity at moment of sepsis diagnosis and during the first week could be used as biomarker to predict the clinical outcome in septic patients.
000130406 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000130406 590__ $$a4.476$$b2014
000130406 591__ $$aCRITICAL CARE MEDICINE$$b5 / 27 = 0.185$$c2014$$dQ1$$eT1
000130406 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130406 700__ $$aMartín, M. M.
000130406 700__ $$0(orcid)0000-0002-3217-1424$$aLópez-Gallardo, E.$$uUniversidad de Zaragoza
000130406 700__ $$aIceta, R.
000130406 700__ $$aBlanquer, J.
000130406 700__ $$aSolé-Violán, J.
000130406 700__ $$aLabarta, L.
000130406 700__ $$aDíaz, C.
000130406 700__ $$0(orcid)0000-0003-1770-6299$$aJiménez, A.$$uUniversidad de Zaragoza
000130406 700__ $$aMontoya, J.
000130406 700__ $$0(orcid)0000-0002-0269-7337$$aRuiz-Pesini, E.$$uUniversidad de Zaragoza
000130406 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000130406 773__ $$g18, 3 (2014), R136 [17 pp]$$pCrit. care$$tCritical care$$x1364-8535
000130406 8564_ $$s546702$$uhttps://zaguan.unizar.es/record/130406/files/texto_completo.pdf$$yVersión publicada
000130406 8564_ $$s2607695$$uhttps://zaguan.unizar.es/record/130406/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130406 909CO $$ooai:zaguan.unizar.es:130406$$particulos$$pdriver
000130406 951__ $$a2024-01-25-15:08:03
000130406 980__ $$aARTICLE