130406 20240125162930.0 doi 10.1186/cc13956 sideral 98813 ART-2014-98813 eng Lorente, L. Higher platelet cytochrome oxidase specific activity in surviving than in non-surviving septic patients 2014 Introduction: In a previous study with 96 septic patients, we found that circulating platelets in 6-months surviving septic patients showed higher activity and quantity of cytochrome c oxidase (COX) normalized by citrate synthase (CS) activity at moment of severe sepsis diagnosis than non-surviving septic patients. The objective of this study was to estimate whether COX specific activity during the first week predicts 1-month sepsis survival in a larger cohort of patients.Methods: Using a prospective, multicenter, observational study carried out in six Spanish intensive care units with 198 severe septic patients, we determined COX activity per proteins (COXact/Prot) in circulating platelets at day 1, 4 and 8 of the severe sepsis diagnosis. Endpoints were 1-month and 6-months mortality.Results: Survivor patients (n = 130) showed higher COXact/Prot (P 0.30 mOD/min/mg at day 1 (P = 0.002), 4 (P = 0.006) and 8 (P = 0.02) was associated independently with 1-month mortality. Area under the curve of COXact/Prot at day 1, 4 and 8 to predict 30-day survival were 0.70 (95% CI = 0.63-0.76; P < 0.001), 0.71 (95% CI = 0.64-0.77; P < 0.001) and 0.71 (95% CI = 0.64-0.78; P < 0.001), respectively.Conclusions: The new findings of our study, to our knowledge the largest series reporting data about mitochondrial function during follow-up in septic patients, were that septic patients that survive 1-month have a higher platelet cytochrome oxidase activity at moment of sepsis diagnosis and during the first week than non-survivors, and that platelet cytochrome oxidase activity at moment of sepsis diagnosis and during the first week could be used as biomarker to predict the clinical outcome in septic patients. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.476 2014 CRITICAL CARE MEDICINE 5 / 27 = 0.185 2014 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Martín, M. M. López-Gallardo, E. Universidad de Zaragoza (orcid)0000-0002-3217-1424 Iceta, R. Blanquer, J. Solé-Violán, J. Labarta, L. Díaz, C. Jiménez, A. Universidad de Zaragoza (orcid)0000-0003-1770-6299 Montoya, J. Ruiz-Pesini, E. Universidad de Zaragoza (orcid)0000-0002-0269-7337 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 18, 3 (2014), R136 [17 pp] Crit. care Critical care 1364-8535 546702 http://zaguan.unizar.es/record/130406/files/texto_completo.pdf Versión publicada 2607695 http://zaguan.unizar.es/record/130406/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130406 articulos driver 2024-01-25-15:08:03 ARTICLE