000130408 001__ 130408 000130408 005__ 20240125162930.0 000130408 0247_ $$2doi$$a10.1016/j.mrrev.2011.06.004 000130408 0248_ $$2sideral$$a74662 000130408 037__ $$aART-2011-74662 000130408 041__ $$aeng 000130408 100__ $$0(orcid)0000-0002-3217-1424$$aLópez-Gallardo,E.$$uUniversidad de Zaragoza 000130408 245__ $$aOXPHOS toxicogenomics and Parkinson's disease 000130408 260__ $$c2011 000130408 5203_ $$aActivities and quantities of several oxidative phosphorylation (OXPHOS) system complexes are decreased in many Parkinson's disease (PD) patients. Mutations in PD-associated nuclear genes affect OXPHOS function. Moreover, the inactivation of other nuclear genes related to mitochondrial DNA (mtDNA) replication and expression also leads to Parkinsonism. MtDNA only encodes OXPHOS subunits and the RNAs required for their expression. Mutations in mtDNA genes have also been associated with PD. Furthermore, many xenobiotics that inhibit different OXPHOS complexes provoke Parkinsonism. The binding sites for these venoms are usually mtDNA-encoded subunits. However, and despite the existence of mutations or toxicants that can cause Parkinsonism, PD only rarely results from isolated genetic or environmental factors. Combinations of nuclear and mitochondrial genetic and environmental factors have additive effects and increase the risk of PD. It is also possible that population polymorphisms in mtDNA genes, affecting interactions with different xenobiotics, may behave as susceptibility factors for developing PD only in the presence of that particular xenobiotic. Therefore, a deeper analysis of the OXPHOS function in PD is required if we want to unravel the complexities of this disorder. 000130408 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000130408 590__ $$a6.462$$b2011 000130408 591__ $$aBIOTECHNOLOGY & APPLIED MICROBIOLOGY$$b11 / 158 = 0.07$$c2011$$dQ1$$eT1 000130408 591__ $$aTOXICOLOGY$$b3 / 83 = 0.036$$c2011$$dQ1$$eT1 000130408 591__ $$aGENETICS & HEREDITY$$b15 / 156 = 0.096$$c2011$$dQ1$$eT1 000130408 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000130408 700__ $$aIceta,R.$$uUniversidad de Zaragoza 000130408 700__ $$0(orcid)0000-0003-1508-6516$$aIglesias,E. 000130408 700__ $$0(orcid)0000-0003-1770-6299$$aMontoya,J.$$uUniversidad de Zaragoza 000130408 700__ $$0(orcid)0000-0002-0269-7337$$aRuiz-Pesini,E.$$uUniversidad de Zaragoza 000130408 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología 000130408 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole. 000130408 773__ $$g728, 3 (2011)$$pMutat. res., Rev. mutat. res.$$tMUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH$$x1383-5742 000130408 8564_ $$s555721$$uhttps://zaguan.unizar.es/record/130408/files/texto_completo.pdf$$yVersión publicada 000130408 8564_ $$s2247805$$uhttps://zaguan.unizar.es/record/130408/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000130408 909CO $$ooai:zaguan.unizar.es:130408$$particulos$$pdriver 000130408 951__ $$a2024-01-25-15:08:17 000130408 980__ $$aARTICLE