130408 20240125162930.0 doi 10.1016/j.mrrev.2011.06.004 sideral 74662 ART-2011-74662 eng López-Gallardo,E. Universidad de Zaragoza (orcid)0000-0002-3217-1424 OXPHOS toxicogenomics and Parkinson's disease 2011 Activities and quantities of several oxidative phosphorylation (OXPHOS) system complexes are decreased in many Parkinson's disease (PD) patients. Mutations in PD-associated nuclear genes affect OXPHOS function. Moreover, the inactivation of other nuclear genes related to mitochondrial DNA (mtDNA) replication and expression also leads to Parkinsonism. MtDNA only encodes OXPHOS subunits and the RNAs required for their expression. Mutations in mtDNA genes have also been associated with PD. Furthermore, many xenobiotics that inhibit different OXPHOS complexes provoke Parkinsonism. The binding sites for these venoms are usually mtDNA-encoded subunits. However, and despite the existence of mutations or toxicants that can cause Parkinsonism, PD only rarely results from isolated genetic or environmental factors. Combinations of nuclear and mitochondrial genetic and environmental factors have additive effects and increase the risk of PD. It is also possible that population polymorphisms in mtDNA genes, affecting interactions with different xenobiotics, may behave as susceptibility factors for developing PD only in the presence of that particular xenobiotic. Therefore, a deeper analysis of the OXPHOS function in PD is required if we want to unravel the complexities of this disorder. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 6.462 2011 BIOTECHNOLOGY & APPLIED MICROBIOLOGY 11 / 158 = 0.07 2011 Q1 T1 TOXICOLOGY 3 / 83 = 0.036 2011 Q1 T1 GENETICS & HEREDITY 15 / 156 = 0.096 2011 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Iceta,R. Universidad de Zaragoza Iglesias,E. (orcid)0000-0003-1508-6516 Montoya,J. Universidad de Zaragoza (orcid)0000-0003-1770-6299 Ruiz-Pesini,E. Universidad de Zaragoza (orcid)0000-0002-0269-7337 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 728, 3 (2011) Mutat. res., Rev. mutat. res. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 1383-5742 555721 http://zaguan.unizar.es/record/130408/files/texto_completo.pdf Versión publicada 2247805 http://zaguan.unizar.es/record/130408/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130408 articulos driver 2024-01-25-15:08:17 ARTICLE