000130412 001__ 130412
000130412 005__ 20240125162930.0
000130412 0247_ $$2doi$$a10.4012/dmj.2012-015-r
000130412 0248_ $$2sideral$$a86981
000130412 037__ $$aART-2014-86981
000130412 041__ $$aeng
000130412 100__ $$0(orcid)0000-0002-1275-2600$$aSantander, S.$$uUniversidad de Zaragoza
000130412 245__ $$aIn vitro osteoinduction of human mesenchymal stem cells in biomimetic surface modified titanium alloy implants
000130412 260__ $$c2014
000130412 5203_ $$aInteraction between cells and implant surface is crucial for clinical success. This interaction and the associated surface treatment are essential for achieving a fast osseointegration process. Several studies of different topographical or chemical surface modifications have been proposed previously in literature. The Biomimetic Advanced Surface (BAS) topography is a combination of a shot blasting and anodizing procedure. Macroroughness, microporosity of titanium oxide and Calcium/Phosphate ion deposition is obtained. Human mesenchymal stem cells (hMCSs) response in vitro to this treatment has been evaluated. The results obtained show an improved adhesion capacity and a higher proliferation rate when hMSCs are cultured on treated surfaces. This biomimetic modification of the titanium surface induces the expression of osteblastic differentiation markers (RUNX2 and Osteopontin) in the absence of any externally provided differentiation factor. As a main conclusion, our biomimetic surface modification could lead to a substantial improvement in osteoinduction in titanium alloy implants.
000130412 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130412 590__ $$a0.968$$b2014
000130412 591__ $$aDENTISTRY, ORAL SURGERY & MEDICINE$$b62 / 87 = 0.713$$c2014$$dQ3$$eT3
000130412 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b30 / 33 = 0.909$$c2014$$dQ4$$eT3
000130412 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130412 700__ $$0(orcid)0000-0002-7854-8856$$aAlcaine, C.
000130412 700__ $$aLyahyai, J.
000130412 700__ $$0(orcid)0000-0002-2901-4188$$aPérez, M. A.$$uUniversidad de Zaragoza
000130412 700__ $$0(orcid)0000-0003-3289-2675$$aRodellar, C.$$uUniversidad de Zaragoza
000130412 700__ $$0(orcid)0000-0001-8741-6452$$aDoblaré, M.$$uUniversidad de Zaragoza
000130412 700__ $$0(orcid)0000-0003-2410-5678$$aOchoa, I.$$uUniversidad de Zaragoza
000130412 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000130412 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000130412 7102_ $$11005$$2315$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Farmacología
000130412 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000130412 773__ $$g33, 3 (2014), 305-312$$pDent. mater. j.$$tDENTAL MATERIALS JOURNAL$$x0287-4547
000130412 8564_ $$s1248620$$uhttps://zaguan.unizar.es/record/130412/files/texto_completo.pdf$$yVersión publicada
000130412 8564_ $$s773198$$uhttps://zaguan.unizar.es/record/130412/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130412 909CO $$ooai:zaguan.unizar.es:130412$$particulos$$pdriver
000130412 951__ $$a2024-01-25-15:08:39
000130412 980__ $$aARTICLE