130412 20240125162930.0 doi 10.4012/dmj.2012-015-r sideral 86981 ART-2014-86981 eng Santander, S. Universidad de Zaragoza (orcid)0000-0002-1275-2600 In vitro osteoinduction of human mesenchymal stem cells in biomimetic surface modified titanium alloy implants 2014 Interaction between cells and implant surface is crucial for clinical success. This interaction and the associated surface treatment are essential for achieving a fast osseointegration process. Several studies of different topographical or chemical surface modifications have been proposed previously in literature. The Biomimetic Advanced Surface (BAS) topography is a combination of a shot blasting and anodizing procedure. Macroroughness, microporosity of titanium oxide and Calcium/Phosphate ion deposition is obtained. Human mesenchymal stem cells (hMCSs) response in vitro to this treatment has been evaluated. The results obtained show an improved adhesion capacity and a higher proliferation rate when hMSCs are cultured on treated surfaces. This biomimetic modification of the titanium surface induces the expression of osteblastic differentiation markers (RUNX2 and Osteopontin) in the absence of any externally provided differentiation factor. As a main conclusion, our biomimetic surface modification could lead to a substantial improvement in osteoinduction in titanium alloy implants. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 0.968 2014 DENTISTRY, ORAL SURGERY & MEDICINE 62 / 87 = 0.713 2014 Q3 T3 MATERIALS SCIENCE, BIOMATERIALS 30 / 33 = 0.909 2014 Q4 T3 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Alcaine, C. (orcid)0000-0002-7854-8856 Lyahyai, J. Pérez, M. A. Universidad de Zaragoza (orcid)0000-0002-2901-4188 Rodellar, C. Universidad de Zaragoza (orcid)0000-0003-3289-2675 Doblaré, M. Universidad de Zaragoza (orcid)0000-0001-8741-6452 Ochoa, I. Universidad de Zaragoza (orcid)0000-0003-2410-5678 1001 420 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Genética 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 1005 315 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Farmacología 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 33, 3 (2014), 305-312 Dent. mater. j. DENTAL MATERIALS JOURNAL 0287-4547 1248620 http://zaguan.unizar.es/record/130412/files/texto_completo.pdf Versión publicada 773198 http://zaguan.unizar.es/record/130412/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130412 articulos driver 2024-01-25-15:08:39 ARTICLE