000130415 001__ 130415
000130415 005__ 20240125162930.0
000130415 0247_ $$2doi$$a10.1039/c7lc00488e
000130415 0248_ $$2sideral$$a104885
000130415 037__ $$aART-2017-104885
000130415 041__ $$aeng
000130415 100__ $$aLachaux, J.
000130415 245__ $$aThermoplastic elastomer with advanced hydrophilization and bonding performances for rapid (30 s) and easy molding of microfluidic devices
000130415 260__ $$c2017
000130415 5203_ $$aOne of the most important areas of research on microfluidic technologies focuses on the identification and characterisation of novel materials with enhanced properties and versatility. Here we present a fast, easy and inexpensive microstructuration method for the fabrication of novel, flexible, transparent and biocompatible microfluidic devices. Using a simple hot press, we demonstrate the rapid (30 s) production of various microfluidic prototypes embossed in a commercially available soft thermoplastic elastomer (sTPE). This styrenic block copolymer (BCP) material is as flexible as PDMS and as thermoformable as classical thermoplastics. It exhibits high fidelity of replication using SU-8 and epoxy master molds in a highly convenient low-isobar (0.4 bar) and iso-thermal process. Microfluidic devices can then be easily sealed using either a simple hot plate or even a room-temperature assembly, allowing them to sustain liquid pressures of 2 and 0.6 bar, respectively. The excellent sorption and biocompatibility properties of the microchips were validated via a standard rhodamine dye assay as well as a sensitive yeast cell-based assay. The morphology and composition of the surface area after plasma treatment for hydrophilization purposes are stable and show constant and homogenous distribution of block nanodomains (~22° after 4 days). These domains, which are evenly distributed on the nanoscale, therefore account for the uniform and convenient surface of a "microfluidic scale device". To our knowledge, this is the first thermoplastic elastomer material that can be used for fast and reliable fabrication and assembly of microdevices while maintaining a high and stable hydrophilicity.
000130415 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/BIO2016-79092-R$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/DPI2015-65401-C3-1-R
000130415 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130415 590__ $$a5.995$$b2017
000130415 591__ $$aBIOCHEMICAL RESEARCH METHODS$$b5 / 77 = 0.065$$c2017$$dQ1$$eT1
000130415 591__ $$aCHEMISTRY, ANALYTICAL$$b5 / 78 = 0.064$$c2017$$dQ1$$eT1
000130415 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b32 / 169 = 0.189$$c2017$$dQ1$$eT1
000130415 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b24 / 91 = 0.264$$c2017$$dQ2$$eT1
000130415 592__ $$a2.158$$b2017
000130415 593__ $$aBiochemistry$$c2017$$dQ1
000130415 593__ $$aBioengineering$$c2017$$dQ1
000130415 593__ $$aNanoscience and Nanotechnology$$c2017$$dQ1
000130415 593__ $$aChemistry (miscellaneous)$$c2017$$dQ1
000130415 593__ $$aBiomedical Engineering$$c2017$$dQ1
000130415 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130415 700__ $$0(orcid)0000-0002-7854-8856$$aAlcaine, C.
000130415 700__ $$aGómez-Escoda, B.
000130415 700__ $$aPerrault, C.M.
000130415 700__ $$aDuplan, D.O.
000130415 700__ $$aWu, P.Y.J.
000130415 700__ $$0(orcid)0000-0003-2410-5678$$aOchoa, I.$$uUniversidad de Zaragoza
000130415 700__ $$0(orcid)0000-0001-5376-4440$$aFernandez, L.$$uUniversidad de Zaragoza
000130415 700__ $$aMercier, O.
000130415 700__ $$aCoudreuse, D.
000130415 700__ $$aRoy, E.
000130415 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000130415 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000130415 773__ $$g17, 15 (2017), 2581-2594$$pLab chip$$tLab on a chip$$x1473-0197
000130415 8564_ $$s10843492$$uhttps://zaguan.unizar.es/record/130415/files/texto_completo.pdf$$yVersión publicada
000130415 8564_ $$s1455480$$uhttps://zaguan.unizar.es/record/130415/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130415 909CO $$ooai:zaguan.unizar.es:130415$$particulos$$pdriver
000130415 951__ $$a2024-01-25-15:09:05
000130415 980__ $$aARTICLE