130415 20240125162930.0 doi 10.1039/c7lc00488e sideral 104885 ART-2017-104885 eng Lachaux, J. Thermoplastic elastomer with advanced hydrophilization and bonding performances for rapid (30 s) and easy molding of microfluidic devices 2017 One of the most important areas of research on microfluidic technologies focuses on the identification and characterisation of novel materials with enhanced properties and versatility. Here we present a fast, easy and inexpensive microstructuration method for the fabrication of novel, flexible, transparent and biocompatible microfluidic devices. Using a simple hot press, we demonstrate the rapid (30 s) production of various microfluidic prototypes embossed in a commercially available soft thermoplastic elastomer (sTPE). This styrenic block copolymer (BCP) material is as flexible as PDMS and as thermoformable as classical thermoplastics. It exhibits high fidelity of replication using SU-8 and epoxy master molds in a highly convenient low-isobar (0.4 bar) and iso-thermal process. Microfluidic devices can then be easily sealed using either a simple hot plate or even a room-temperature assembly, allowing them to sustain liquid pressures of 2 and 0.6 bar, respectively. The excellent sorption and biocompatibility properties of the microchips were validated via a standard rhodamine dye assay as well as a sensitive yeast cell-based assay. The morphology and composition of the surface area after plasma treatment for hydrophilization purposes are stable and show constant and homogenous distribution of block nanodomains (~22° after 4 days). These domains, which are evenly distributed on the nanoscale, therefore account for the uniform and convenient surface of a "microfluidic scale device". To our knowledge, this is the first thermoplastic elastomer material that can be used for fast and reliable fabrication and assembly of microdevices while maintaining a high and stable hydrophilicity. info:eu-repo/grantAgreement/ES/MINECO/BIO2016-79092-R info:eu-repo/grantAgreement/ES/MINECO-FEDER/DPI2015-65401-C3-1-R info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 5.995 2017 BIOCHEMICAL RESEARCH METHODS 5 / 77 = 0.065 2017 Q1 T1 CHEMISTRY, ANALYTICAL 5 / 78 = 0.064 2017 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 32 / 169 = 0.189 2017 Q1 T1 NANOSCIENCE & NANOTECHNOLOGY 24 / 91 = 0.264 2017 Q2 T1 2.158 2017 Biochemistry 2017 Q1 Bioengineering 2017 Q1 Nanoscience and Nanotechnology 2017 Q1 Chemistry (miscellaneous) 2017 Q1 Biomedical Engineering 2017 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Alcaine, C. (orcid)0000-0002-7854-8856 Gómez-Escoda, B. Perrault, C.M. Duplan, D.O. Wu, P.Y.J. Ochoa, I. Universidad de Zaragoza (orcid)0000-0003-2410-5678 Fernandez, L. Universidad de Zaragoza (orcid)0000-0001-5376-4440 Mercier, O. Coudreuse, D. Roy, E. 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 17, 15 (2017), 2581-2594 Lab chip Lab on a chip 1473-0197 10843492 http://zaguan.unizar.es/record/130415/files/texto_completo.pdf Versión publicada 1455480 http://zaguan.unizar.es/record/130415/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130415 articulos driver 2024-01-25-15:09:05 ARTICLE