000130442 001__ 130442 000130442 005__ 20250130163245.0 000130442 0247_ $$2doi$$a10.1002/mnfr.201800136 000130442 0248_ $$2sideral$$a107739 000130442 037__ $$aART-2018-107739 000130442 041__ $$aeng 000130442 100__ $$0(orcid)0000-0001-9578-6525$$aLou-Bonafonte, J.M.$$uUniversidad de Zaragoza 000130442 245__ $$aCurrent Insights into the Biological Action of Squalene 000130442 260__ $$c2018 000130442 5060_ $$aAccess copy available to the general public$$fUnrestricted 000130442 5203_ $$aSqualene is a triterpenic compound found in a large number of plants and other sources with a long tradition of research since it was first reported in 1926. Herein a systematic review of studies concerning squalene published in the last 8 years is presented. These studies have provided further support for its antioxidant, anti-inflammatory, and anti-atherosclerotic properties in vivo and in vitro. Moreover, an antineoplastic effect in nutrigenetic-type treatments, which depends on the failing metabolic pathway of tumors, has also been reported. The bioavailability of squalene in cell cultures, animal models, and in humans has been well established, and further progress has been made in regard to the intracellular transport of this lipophilic molecule. Squalene accumulates in the liver and decreases hepatic cholesterol and triglycerides, with these actions being exerted via a complex network of changes in gene expression at both transcriptional and post-transcriptional levels. Its presence in different biological fluids has also been studied. The combination of squalene with other bioactive compounds has been shown to enhance its pleiotropic properties and might lead to the formulation of functional foods and nutraceuticals to control oxidative stress and, therefore, numerous age-related diseases in human and veterinary medicine. 000130442 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B69$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2013-41651-R$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R 000130442 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000130442 590__ $$a4.653$$b2018 000130442 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b9 / 135 = 0.067$$c2018$$dQ1$$eT1 000130442 592__ $$a1.476$$b2018 000130442 593__ $$aFood Science$$c2018$$dQ1 000130442 593__ $$aBiotechnology$$c2018$$dQ1 000130442 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/acceptedVersion 000130442 700__ $$0(orcid)0000-0002-8100-5596$$aMartínez-Beamonte, R.$$uUniversidad de Zaragoza 000130442 700__ $$0(orcid)0000-0002-5407-3876$$aSanclemente, T. 000130442 700__ $$0(orcid)0000-0002-5841-0462$$aSurra, J.C.$$uUniversidad de Zaragoza 000130442 700__ $$0(orcid)0000-0002-4665-9674$$aHerrera-Marcos, L.V.$$uUniversidad de Zaragoza 000130442 700__ $$0(orcid)0000-0002-9023-741X$$aSanchez-Marco, J. 000130442 700__ $$0(orcid)0000-0003-1197-4276$$aArnal, C.$$uUniversidad de Zaragoza 000130442 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, J.$$uUniversidad de Zaragoza 000130442 7102_ $$12008$$2640$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Nutrición Bromatología 000130442 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología 000130442 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal 000130442 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal 000130442 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole. 000130442 773__ $$g62, 15 (2018), 1800136 [16 pp]$$pMOL NUTR FOOD RES$$tMOLECULAR NUTRITION & FOOD RESEARCH$$x1613-4125 000130442 8564_ $$s2142925$$uhttps://zaguan.unizar.es/record/130442/files/texto_completo.pdf$$yVersión publicada 000130442 8564_ $$s1815349$$uhttps://zaguan.unizar.es/record/130442/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000130442 909CO $$ooai:zaguan.unizar.es:130442$$particulos$$pdriver 000130442 951__ $$a2025-01-30-16:31:06 000130442 980__ $$aARTICLE