000130451 001__ 130451
000130451 005__ 20240130142254.0
000130451 0247_ $$2doi$$a10.1177/2047487319896138
000130451 0248_ $$2sideral$$a116515
000130451 037__ $$aART-2020-116515
000130451 041__ $$aeng
000130451 100__ $$0(orcid)0000-0002-1894-1621$$aPerez-Calahorra, S.$$uUniversidad de Zaragoza
000130451 245__ $$aBehavioural cardiovascular risk factors and prevalence of diabetes in subjects with familial hypercholesterolaemia
000130451 260__ $$c2020
000130451 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130451 5203_ $$aA low prevalence of type 2 diabetes mellitus has been reported in familial hypercholesterolaemia. Whether a healthier lifestyle could explain it has not been explored. This cross-sectional study determines the prevalence of lifestyle-related cardiovascular risk factors in heterozygous familial hypercholesterolaemia (HeFH) from the Dyslipidaemia Registry of the Spanish Atherosclerosis Society and in the ENRICA study, a representative sample of the adult Spanish general population, weighted to match the age and sex distribution of the HeFH sample. A total of 2185 HeFH patients and 11, 856 individuals from ENRICA were included. HeFH had lower body mass index and fewer of them were smokers than in the reference population. A model adjusted for age, sex and body mass index showed that HeFH more frequently had cardiovascular disease (odds ratio (OR) 23.98; 95% confidence interval (CI) 18.40–31.23) and hypertension (OR 1.20; 95% CI 1.07–1.35), and took anti-hypertensive medication (OR 1.36; 95% CI 1.18–1.56) and anti-diabetic medication (OR 1.25; 95% CI 1.00–1.56), but less frequently were smokers (OR 0.79; 95% CI 0.71–0.89). In a HeFH subsample (n = 513) with complete blood glucose information, those patients without cardiovascular disease showed lower prevalence of smoking and type 2 diabetes mellitus, lower body mass index and glucose, and higher diastolic blood pressure than the Spanish population. The differences in type 2 diabetes mellitus were justified mostly by the difference in body mass index. Body mass index adjustment also showed higher prevalence of hypertension and use of anti-hypertensive drugs in HeFH. In summary, HeFH patients had lower body mass index, which may contribute to explaining the lower prevalence of diabetes, and lower current smoking but higher hypertension. © The European Society of Cardiology 2020.
000130451 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-ERDF/CIBERCV-CB16-11-00451
000130451 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130451 590__ $$a7.804$$b2020
000130451 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b18 / 141 = 0.128$$c2020$$dQ1$$eT1
000130451 592__ $$a1.669$$b2020
000130451 593__ $$aCardiology and Cardiovascular Medicine$$c2020$$dQ1
000130451 593__ $$aEpidemiology$$c2020$$dQ1
000130451 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000130451 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, F.$$uUniversidad de Zaragoza
000130451 700__ $$aGuallar-Castillón, P.
000130451 700__ $$aPinto, X.
000130451 700__ $$aBanegas, J. R.
000130451 700__ $$aPedro-Botet, J.
000130451 700__ $$aSuarez-Tembra, M.
000130451 700__ $$aMauri, M.
000130451 700__ $$aSoler, C.
000130451 700__ $$aRodriguez-Artalejo, F.
000130451 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, M.$$uUniversidad de Zaragoza
000130451 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000130451 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000130451 773__ $$g27, 15 (2020), 1649-1660$$pEur. j. prev. cardiol.$$tEuropean Journal of Preventive Cardiology$$x2047-4873
000130451 8564_ $$s268882$$uhttps://zaguan.unizar.es/record/130451/files/texto_completo.pdf$$yPostprint
000130451 8564_ $$s951011$$uhttps://zaguan.unizar.es/record/130451/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000130451 909CO $$ooai:zaguan.unizar.es:130451$$particulos$$pdriver
000130451 951__ $$a2024-01-30-14:18:41
000130451 980__ $$aARTICLE