000130499 001__ 130499 000130499 005__ 20240125162931.0 000130499 0247_ $$2doi$$a10.1016/j.drudis.2012.04.012 000130499 0248_ $$2sideral$$a79061 000130499 037__ $$aART-2012-79061 000130499 041__ $$aeng 000130499 100__ $$0(orcid)0000-0003-2645-3983$$aPacheu-Grau,D.$$uUniversidad de Zaragoza 000130499 245__ $$aRead-through therapy for mitochondrial DNA nonsense mutations 000130499 260__ $$c2012 000130499 5203_ $$aDisorders resulting from mitochondrial DNA (mtDNA) mutations, including nonsense mutations, do not yet have causal treatments. As we discuss here, read-through therapies appear to be a promising approach to the treatment of disorders arising from nuclear DNA (nDNA) nonsense mutations. The genetics of mitochondrial DNA suggest that this therapy will also be successful in the treatment of mitochondriopathies. 000130499 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000130499 590__ $$a6.551$$b2012 000130499 591__ $$aPHARMACOLOGY & PHARMACY$$b12 / 259 = 0.046$$c2012$$dQ1$$eT1 000130499 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000130499 700__ $$aGómez-Durán,A.$$uUniversidad de Zaragoza 000130499 700__ $$0(orcid)0000-0002-3217-1424$$aLópez-Gallardo,E.$$uUniversidad de Zaragoza 000130499 700__ $$0(orcid)0000-0003-1770-6299$$aMontoya,J.$$uUniversidad de Zaragoza 000130499 700__ $$0(orcid)0000-0002-0269-7337$$aRuiz-Pesini,E.$$uUniversidad de Zaragoza 000130499 7102_ $$11008$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Inmunología 000130499 7102_ $$11002$$2X$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cProy. investigación DEA 000130499 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole. 000130499 773__ $$g17, 19-20 (2012), 1063-1067$$pDrug discov. today$$tDRUG DISCOVERY TODAY$$x1359-6446 000130499 8564_ $$s141413$$uhttps://zaguan.unizar.es/record/130499/files/texto_completo.pdf$$yVersión publicada 000130499 8564_ $$s2230979$$uhttps://zaguan.unizar.es/record/130499/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000130499 909CO $$ooai:zaguan.unizar.es:130499$$particulos$$pdriver 000130499 951__ $$a2024-01-25-15:15:41 000130499 980__ $$aARTICLE