000130501 001__ 130501
000130501 005__ 20240125162931.0
000130501 0247_ $$2doi$$a10.1016/j.mito.2013.04.001
000130501 0248_ $$2sideral$$a81822
000130501 037__ $$aART-2013-81822
000130501 041__ $$aeng
000130501 100__ $$aMontero, R.
000130501 245__ $$aCoenzyme Q10 deficiency in mitochondrial DNA depletion syndromes
000130501 260__ $$c2013
000130501 5203_ $$aWe evaluated coenzyme Q10 (CoQ) levels in patients studied under suspicion of mitochondrial DNA depletion syndromes (MDS) (n = 39). CoQ levels were quantified by HPLC, and the percentage of mtDNA depletion by quantitative real-time PCR. A high percentage of MDS patients presented with CoQ deficiency as compared to other mitochondrial patients (Mann–Whitney-U test: p = 0.001). Our findings suggest that MDS are frequently associated with CoQ deficiency, as a possible secondary consequence of disease pathophysiology. Assessment of muscle CoQ status seems advisable in MDS patients since the possibility of CoQ supplementation may then be considered as a candidate therapy.
000130501 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130501 590__ $$a3.524$$b2013
000130501 591__ $$aGENETICS & HEREDITY$$b52 / 164 = 0.317$$c2013$$dQ2$$eT1
000130501 591__ $$aCELL BIOLOGY$$b85 / 184 = 0.462$$c2013$$dQ2$$eT2
000130501 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130501 700__ $$aGrazina, M.
000130501 700__ $$0(orcid)0000-0002-3217-1424$$aLópez-Gallardo, E.$$uUniversidad de Zaragoza
000130501 700__ $$0(orcid)0000-0003-1770-6299$$aMontoya, J.$$uUniversidad de Zaragoza
000130501 700__ $$aBriones, P.
000130501 700__ $$aNavarro-Sastre, A.
000130501 700__ $$aLand, J. M.
000130501 700__ $$aHargreaves, I. P.
000130501 700__ $$aArtuch, R.
000130501 700__ $$adel, Mar O.
000130501 700__ $$aJou, C.
000130501 700__ $$aJimenez, C.
000130501 700__ $$aBuján, N.
000130501 700__ $$aPineda, M.
000130501 700__ $$aGarcía-Cazorla, A.
000130501 700__ $$aNascimento, A.
000130501 700__ $$aPerez-Dueñas, B.
000130501 700__ $$0(orcid)0000-0002-0269-7337$$aRuiz-Pesini, E.$$uUniversidad de Zaragoza
000130501 700__ $$aFratter, C.
000130501 700__ $$aSalviati, L.
000130501 700__ $$aSimões, M.
000130501 700__ $$aMendes, C.
000130501 700__ $$aJoãoSantos, M.
000130501 700__ $$aDiogo, L.
000130501 700__ $$aGarcia, P.
000130501 700__ $$aNavas, P.
000130501 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000130501 773__ $$g13, 4 (2013), 337-341$$pMitochondrion$$tMITOCHONDRION$$x1567-7249
000130501 8564_ $$s189049$$uhttps://zaguan.unizar.es/record/130501/files/texto_completo.pdf$$yVersión publicada
000130501 8564_ $$s2853691$$uhttps://zaguan.unizar.es/record/130501/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130501 909CO $$ooai:zaguan.unizar.es:130501$$particulos$$pdriver
000130501 951__ $$a2024-01-25-15:15:51
000130501 980__ $$aARTICLE