130501 20240125162931.0 doi 10.1016/j.mito.2013.04.001 sideral 81822 ART-2013-81822 eng Montero, R. Coenzyme Q10 deficiency in mitochondrial DNA depletion syndromes 2013 We evaluated coenzyme Q10 (CoQ) levels in patients studied under suspicion of mitochondrial DNA depletion syndromes (MDS) (n = 39). CoQ levels were quantified by HPLC, and the percentage of mtDNA depletion by quantitative real-time PCR. A high percentage of MDS patients presented with CoQ deficiency as compared to other mitochondrial patients (Mann–Whitney-U test: p = 0.001). Our findings suggest that MDS are frequently associated with CoQ deficiency, as a possible secondary consequence of disease pathophysiology. Assessment of muscle CoQ status seems advisable in MDS patients since the possibility of CoQ supplementation may then be considered as a candidate therapy. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.524 2013 GENETICS & HEREDITY 52 / 164 = 0.317 2013 Q2 T1 CELL BIOLOGY 85 / 184 = 0.462 2013 Q2 T2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Grazina, M. López-Gallardo, E. Universidad de Zaragoza (orcid)0000-0002-3217-1424 Montoya, J. Universidad de Zaragoza (orcid)0000-0003-1770-6299 Briones, P. Navarro-Sastre, A. Land, J. M. Hargreaves, I. P. Artuch, R. del, Mar O. Jou, C. Jimenez, C. Buján, N. Pineda, M. García-Cazorla, A. Nascimento, A. Perez-Dueñas, B. Ruiz-Pesini, E. Universidad de Zaragoza (orcid)0000-0002-0269-7337 Fratter, C. Salviati, L. Simões, M. Mendes, C. JoãoSantos, M. Diogo, L. Garcia, P. Navas, P. 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 13, 4 (2013), 337-341 Mitochondrion MITOCHONDRION 1567-7249 189049 http://zaguan.unizar.es/record/130501/files/texto_completo.pdf Versión publicada 2853691 http://zaguan.unizar.es/record/130501/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130501 articulos driver 2024-01-25-15:15:51 ARTICLE