000130503 001__ 130503
000130503 005__ 20240125162931.0
000130503 0247_ $$2doi$$a10.1016/j.jcrc.2015.05.031
000130503 0248_ $$2sideral$$a92028
000130503 037__ $$aART-2015-92028
000130503 041__ $$aeng
000130503 100__ $$aLorente, L.
000130503 245__ $$aDecrease of oxidative phosphorylation system function in severe septic patients
000130503 260__ $$c2015
000130503 5203_ $$aObjective
The comparison of oxidative phosphorylation system capacities between septic patients and control subjects has been scarcely analyzed and only in studies with small sample size (fewer than 40 septic patients and 40 controls). Thus, the objective of this study was to compare platelet respiratory complex IV (CIV) activity between severe septic patients and healthy individuals in a larger series (including 198 severe septic patients and 96 healthy controls).
Methods
A prospective, multicenter, observational study was carried out in 6 Spanish intensive care units. We obtained blood samples from 198 severe septic patients at day 1, 4, and 8 of the severe sepsis diagnosis and 96 sex- and age-matched healthy control individuals and determined platelet CIV-specific activity. The end point of the study was 30-day mortality.
Results
Control individuals showed higher platelet CIV-specific activity (P < .001) than surviving (n = 130) or nonsurviving (n = 68) severe septic patients at day 1, 4, and 8 of severe sepsis diagnosis.
Conclusions
The major finding of our work, involving the largest series to date of severe septic patients with data on oxidative phosphorylation system capacity, was that surviving and nonsurviving septic patients showed lower platelet CIV-specific activity during the first week of sepsis than healthy controls.
000130503 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130503 590__ $$a2.445$$b2015
000130503 591__ $$aCRITICAL CARE MEDICINE$$b18 / 33 = 0.545$$c2015$$dQ3$$eT2
000130503 592__ $$a1.186$$b2015
000130503 593__ $$aCritical Care and Intensive Care Medicine$$c2015$$dQ1
000130503 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130503 700__ $$aMartín, M. M.
000130503 700__ $$0(orcid)0000-0002-3217-1424$$aLópez-Gallardo, E.$$uUniversidad de Zaragoza
000130503 700__ $$aBlanquer, J.
000130503 700__ $$aSolé-Violán, J.
000130503 700__ $$aLabarta, L.
000130503 700__ $$aDíaz, C.
000130503 700__ $$0(orcid)0000-0003-1770-6299$$aJiménez, A.$$uUniversidad de Zaragoza
000130503 700__ $$aMontoya, J.
000130503 700__ $$0(orcid)0000-0002-0269-7337$$aRuiz-Pesini, E.$$uUniversidad de Zaragoza
000130503 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000130503 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000130503 773__ $$g30, 5 (2015), 935-939$$pJ. crit. care$$tJOURNAL OF CRITICAL CARE$$x0883-9441
000130503 8564_ $$s285177$$uhttps://zaguan.unizar.es/record/130503/files/texto_completo.pdf$$yVersión publicada
000130503 8564_ $$s2596974$$uhttps://zaguan.unizar.es/record/130503/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130503 909CO $$ooai:zaguan.unizar.es:130503$$particulos$$pdriver
000130503 951__ $$a2024-01-25-15:15:56
000130503 980__ $$aARTICLE