130503 20240125162931.0 doi 10.1016/j.jcrc.2015.05.031 sideral 92028 ART-2015-92028 eng Lorente, L. Decrease of oxidative phosphorylation system function in severe septic patients 2015 Objective The comparison of oxidative phosphorylation system capacities between septic patients and control subjects has been scarcely analyzed and only in studies with small sample size (fewer than 40 septic patients and 40 controls). Thus, the objective of this study was to compare platelet respiratory complex IV (CIV) activity between severe septic patients and healthy individuals in a larger series (including 198 severe septic patients and 96 healthy controls). Methods A prospective, multicenter, observational study was carried out in 6 Spanish intensive care units. We obtained blood samples from 198 severe septic patients at day 1, 4, and 8 of the severe sepsis diagnosis and 96 sex- and age-matched healthy control individuals and determined platelet CIV-specific activity. The end point of the study was 30-day mortality. Results Control individuals showed higher platelet CIV-specific activity (P < .001) than surviving (n = 130) or nonsurviving (n = 68) severe septic patients at day 1, 4, and 8 of severe sepsis diagnosis. Conclusions The major finding of our work, involving the largest series to date of severe septic patients with data on oxidative phosphorylation system capacity, was that surviving and nonsurviving septic patients showed lower platelet CIV-specific activity during the first week of sepsis than healthy controls. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.445 2015 CRITICAL CARE MEDICINE 18 / 33 = 0.545 2015 Q3 T2 1.186 2015 Critical Care and Intensive Care Medicine 2015 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Martín, M. M. López-Gallardo, E. Universidad de Zaragoza (orcid)0000-0002-3217-1424 Blanquer, J. Solé-Violán, J. Labarta, L. Díaz, C. Jiménez, A. Universidad de Zaragoza (orcid)0000-0003-1770-6299 Montoya, J. Ruiz-Pesini, E. Universidad de Zaragoza (orcid)0000-0002-0269-7337 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 30, 5 (2015), 935-939 J. crit. care JOURNAL OF CRITICAL CARE 0883-9441 285177 http://zaguan.unizar.es/record/130503/files/texto_completo.pdf Versión publicada 2596974 http://zaguan.unizar.es/record/130503/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130503 articulos driver 2024-01-25-15:15:56 ARTICLE