000130509 001__ 130509
000130509 005__ 20240125162931.0
000130509 0247_ $$2doi$$a10.1016/j.humpath.2006.02.012
000130509 0248_ $$2sideral$$a129742
000130509 037__ $$aART-2006-129742
000130509 041__ $$aeng
000130509 100__ $$aGallardo, Fernando
000130509 245__ $$aAberrant nuclear BCL10 expression and lack of t(11;18)(q21;q21) in primary cutaneous marginal zone B-cell lymphoma
000130509 260__ $$c2006
000130509 5203_ $$aInhibition of apoptosis seems to play an important role in the pathogenesis of marginal zone lymphoma. Apoptosis regulator B-cell lymphoma 10 (BCL10) may show aberrant nuclear localization in some aggressive extracutaneous MALT lymphomas, often in association with a MALT1 gene t(11;18)(q21;q21) translocation. The possible occurrence of this association in primary cutaneous marginal zone lymphoma (PCMZL) remains insufficiently explored. The aim of this study was to evaluate BCL10 protein expression pattern and its possible relationship to the presence of t(11;18)(q21;q21) and other MALT1 gene abnormalities in PCMZL and to assess their clinical significance. The study included 42 consecutive PCMZL patients diagnosed on the basis of the World Health Organization/European Organization for the Research and Treatment of Cancer classification criteria. BCL10 expression was immunohistochemically evaluated in all cases, whereas t(11;18)(q21;q21) reverse transcriptase polymerase chain reaction amplification was performed on 21 samples. In addition, the presence of other MALT1 gene translocations was explored in 26 samples by interphase fluorescence in situ hybridization using a MALT1 locus-specific probe. We observed the presence of aberrant nuclear BCL10 expression in a significant number of PCMZL cases (36%, 15/42). This aberrant expression was significantly related to the development of extracutaneous disease. In contrast, neither the t(11;18)(q21;q21) translocation nor other MALT1 gene translocations could be demonstrated. t(11;18)(q21;q21), strongly linked to extracutaneous MALT lymphomas, does not seem to play a role in PCMZL. The participation of other MALT1 gene translocations in PCMZL pathogenesis seems also unlikely.
000130509 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130509 590__ $$a2.81$$b2006
000130509 591__ $$aPATHOLOGY$$b14 / 64 = 0.219$$c2006$$dQ1$$eT1
000130509 655_4 $$ainfo:eu-repo/semantics/article
000130509 700__ $$aBellosillo, Beatriz
000130509 700__ $$aEspinet, Blanca
000130509 700__ $$aPujol, Ramon M.
000130509 700__ $$aEstrach, Teresa
000130509 700__ $$aServitje, Octavio
000130509 700__ $$aRomagosa, Vicenç
000130509 700__ $$aBarranco, Carles
000130509 700__ $$aBoluda, Susana
000130509 700__ $$0(orcid)0000-0003-2078-8205$$aGarcía, Mar
000130509 700__ $$aSolé, Francesc
000130509 700__ $$aAriza, Aurelio
000130509 700__ $$aSerrano, Sergi
000130509 773__ $$g37, 7 (2006), 867-873$$pHuman pathol.$$tHUMAN PATHOLOGY$$x0046-8177
000130509 8564_ $$s357567$$uhttps://zaguan.unizar.es/record/130509/files/texto_completo.pdf
000130509 8564_ $$s2062529$$uhttps://zaguan.unizar.es/record/130509/files/texto_completo.jpg?subformat=icon$$xicon
000130509 909CO $$ooai:zaguan.unizar.es:130509$$particulos$$pdriver
000130509 951__ $$a2024-01-25-15:16:30
000130509 980__ $$aARTICLE