000130512 001__ 130512 000130512 005__ 20240125162931.0 000130512 0247_ $$2doi$$a10.1016/j.humpath.2005.08.021 000130512 0248_ $$2sideral$$a129746 000130512 037__ $$aART-2005-129746 000130512 041__ $$aeng 000130512 100__ $$aEspinet, Blanca 000130512 245__ $$aClonal proliferation of cyclin D1-positive mantle lymphocytes in an asymptomatic patient: an early-stage event in the development or an indolent form of a mantle cell lymphoma? 000130512 260__ $$c2005 000130512 5203_ $$aMantle cell lymphoma (MCL) is a B-cell neoplasm with a relatively aggressive clinical course. There is a very small subgroup of patients who present with atypical lymphocytes in peripheral blood, with or without lymphocytosis, lymphadenopathy, or splenomegaly, and with an indolent clinical course. They frequently show mutated IgVH genes and CD5 negativity. We report an asymptomatic elderly patient who presented with a single submandibular lymphadenopathy. The biopsy showed immunophenotype and t(11;14)(q13;q32) consistent with MCL. The abnormal lymphoid population was also detected in peripheral blood and bone marrow. The patient has remained asymptomatic for 5 years without receiving any therapy. It is uncertain whether these cases represent an early-stage event in the development or an indolent form of MCL. The existence of such asymptomatic patients with an indolent clinical course should induce a strict clinical judgment in terms of therapeutic decisions. 000130512 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000130512 590__ $$a2.55$$b2005 000130512 591__ $$aPATHOLOGY$$b18 / 65 = 0.277$$c2005$$dQ2$$eT1 000130512 655_4 $$ainfo:eu-repo/semantics/article 000130512 700__ $$aSolé, Francesc 000130512 700__ $$aPedro, Carme 000130512 700__ $$0(orcid)0000-0003-2078-8205$$aGarcia, Mar 000130512 700__ $$aBellosillo, Beatriz 000130512 700__ $$aSalido, Marta 000130512 700__ $$aFlorensa, Lourdes 000130512 700__ $$aCamacho, Francisca I. 000130512 700__ $$aBaró, Teresa 000130512 700__ $$aLloreta, Josep 000130512 700__ $$aSerrano, Sergi 000130512 773__ $$g36, 11 (2005), 1232-1237$$pHuman pathol.$$tHUMAN PATHOLOGY$$x0046-8177 000130512 8564_ $$s346499$$uhttps://zaguan.unizar.es/record/130512/files/texto_completo.pdf 000130512 8564_ $$s2134187$$uhttps://zaguan.unizar.es/record/130512/files/texto_completo.jpg?subformat=icon$$xicon 000130512 909CO $$ooai:zaguan.unizar.es:130512$$particulos$$pdriver 000130512 951__ $$a2024-01-25-15:16:41 000130512 980__ $$aARTICLE