000130556 001__ 130556 000130556 005__ 20240125162931.0 000130556 0247_ $$2doi$$a10.1016/j.bbabio.2010.08.004 000130556 0248_ $$2sideral$$a72605 000130556 037__ $$aART-2011-72605 000130556 041__ $$aeng 000130556 100__ $$0(orcid)0000-0002-8585-6371$$aBayona-Bafaluy, M.$$uUniversidad de Zaragoza 000130556 245__ $$aMaternally inherited susceptibility to cancer 000130556 260__ $$c2011 000130556 5203_ $$aTumor microenvironment promotes mtDNA mutations. A number of these mutations will affect cell metabolism and increase cell survival. These mutations are positively selected and contribute to other tumor features, such as extracellular matrix remodeling and angiogenic processes, thus favoring metastases. Like somatic mutations, although with less marked effects, some mtDNA population polymorphisms will affect OXPHOS function, cell metabolism, and homeostasis. Thus, they could behave as inherited susceptibility factors for cancer. However, in addition to epidemiological evidence, other more direct clues are required. The cybrid approach can help to clarify this issue. This article is part of a Special Issue entitled: Bioenergetics of Cancer. 000130556 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000130556 590__ $$a4.843$$b2011 000130556 591__ $$aBIOPHYSICS$$b13 / 71 = 0.183$$c2011$$dQ1$$eT1 000130556 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b63 / 287 = 0.22$$c2011$$dQ1$$eT1 000130556 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000130556 700__ $$0(orcid)0000-0002-3217-1424$$aLópez-Gallardo, E.$$uUniversidad de Zaragoza 000130556 700__ $$0(orcid)0000-0003-1770-6299$$aMontoya, J.$$uUniversidad de Zaragoza 000130556 700__ $$0(orcid)0000-0002-0269-7337$$aRuiz-Pesini, E.$$uUniversidad de Zaragoza 000130556 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole. 000130556 773__ $$g1807, 6 (2011), 643-649$$pBiochim. biophys. acta, Bioenerg.$$tBIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS$$x0005-2728 000130556 8564_ $$s487573$$uhttps://zaguan.unizar.es/record/130556/files/texto_completo.pdf$$yVersión publicada 000130556 8564_ $$s1438138$$uhttps://zaguan.unizar.es/record/130556/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000130556 909CO $$ooai:zaguan.unizar.es:130556$$particulos$$pdriver 000130556 951__ $$a2024-01-25-15:19:48 000130556 980__ $$aARTICLE