130556 20240125162931.0 doi 10.1016/j.bbabio.2010.08.004 sideral 72605 ART-2011-72605 eng Bayona-Bafaluy, M. Universidad de Zaragoza (orcid)0000-0002-8585-6371 Maternally inherited susceptibility to cancer 2011 Tumor microenvironment promotes mtDNA mutations. A number of these mutations will affect cell metabolism and increase cell survival. These mutations are positively selected and contribute to other tumor features, such as extracellular matrix remodeling and angiogenic processes, thus favoring metastases. Like somatic mutations, although with less marked effects, some mtDNA population polymorphisms will affect OXPHOS function, cell metabolism, and homeostasis. Thus, they could behave as inherited susceptibility factors for cancer. However, in addition to epidemiological evidence, other more direct clues are required. The cybrid approach can help to clarify this issue. This article is part of a Special Issue entitled: Bioenergetics of Cancer. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.843 2011 BIOPHYSICS 13 / 71 = 0.183 2011 Q1 T1 BIOCHEMISTRY & MOLECULAR BIOLOGY 63 / 287 = 0.22 2011 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion López-Gallardo, E. Universidad de Zaragoza (orcid)0000-0002-3217-1424 Montoya, J. Universidad de Zaragoza (orcid)0000-0003-1770-6299 Ruiz-Pesini, E. Universidad de Zaragoza (orcid)0000-0002-0269-7337 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 1807, 6 (2011), 643-649 Biochim. biophys. acta, Bioenerg. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 0005-2728 487573 http://zaguan.unizar.es/record/130556/files/texto_completo.pdf Versión publicada 1438138 http://zaguan.unizar.es/record/130556/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130556 articulos driver 2024-01-25-15:19:48 ARTICLE