Septic patients with mitochondrial DNA haplogroup JT have higher respiratory complex IV activity and survival rate

Lorente,L. ; Martín,M. M. ; López-Gallardo,E. (Universidad de Zaragoza) ; Ferreres,J. ; Solé-Violán,J. ; Labarta,L. (Universidad de Zaragoza) ; Díaz,C. ; Jiménez,A. ; Montoya,J. (Universidad de Zaragoza) ; Ruiz-Pesini,E. (Universidad de Zaragoza)

Resumen: Objective: The influence of mitochondrial deoxyribonucleic acid (mtDNA) haplogroup or oxidative phosphorylation system (OXPHOS) function on survival of septic patients has been scarcely studied. However, the association between mtDNA haplogroup, OXPHOS capacity at diagnosis of severe sepsis, and survival has been not previously reported, and that was the objective of the present study. Methods: This was a prospective, multicenter, observational study. Blood samples from 198 patients at diagnosis of severe sepsis were analyzed to determine mtDNA haplogroup and platelet respiratory complex IV (CIV) specific activity. The end point of the study was 30-day survival. Results: Septic patients with mtDNA haplogroup JT showed higher 30-day survival than those with mtDNA haplogroup non-JT (31/38 81.6%] vs 99/160 61.9%]; P= .02). Septic patients with mtDNA haplogroup JT showed higher platelet CIV specific activity than those with mtDNA haplogroup non-JT (P= .002). Conclusions: The main novel finding of our study, including the largest series providing data on platelet CIV specific activity according to mtDNA haplogroup in severe septic patients, was that those with mtDNA haplogroup JT showed higher survival and higher platelet CIV specific activity at diagnosis of severe sepsis than patients with mtDNA haplogroup non-JT.

Idioma: Inglés

DOI: 10.1016/j.jcrc.2016.02.003

Año: 2016

Publicado en: JOURNAL OF CRITICAL CARE 33 (2016), 95-99
ISSN: 0883-9441

Factor impacto JCR: 2.648 (2016)

Categ. JCR: CRITICAL CARE MEDICINE rank: 15 / 33 = 0.455 (2016) - Q2 - T2

Factor impacto SCIMAGO: 1.26 - Critical Care and Intensive Care Medicine (Q1)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Area Histología (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)