130565 20240126184244.0 doi 10.1016/j.mito.2016.06.007 sideral 95666 ART-2016-95666 eng Yubero, D. Secondary coenzyme Q10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders 2016 We evaluated the coenzyme Q10 (CoQ) levels in patients who were diagnosed with mitochondrial oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders (n = 72). Data from the 72 cases in this study revealed that 44.4% of patients showed low CoQ concentrations in either their skeletal muscle or skin fibroblasts. Our findings suggest that secondary CoQ deficiency is a common finding in OXPHOS and non-OXPHOS disorders. We hypothesize that cases of CoQ deficiency associated with OXPHOS defects could be an adaptive mechanism to maintain a balanced OXPHOS, although the mechanisms explaining these deficiencies and the pathophysiological role of secondary CoQ deficiency deserves further investigation. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.704 2016 GENETICS & HEREDITY 51 / 165 = 0.309 2016 Q2 T1 CELL BIOLOGY 82 / 188 = 0.436 2016 Q2 T2 1.852 2016 Molecular Medicine 2016 Q1 Cell Biology 2016 Q2 Molecular Biology 2016 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Montero, R. Martín, M. A. Montoya, J. Universidad de Zaragoza (orcid)0000-0003-1770-6299 Ribes, A. Grazina, M. Trevisson, E. Rodriguez-Aguilera, J. Hargreaves, I. P. Salviati, L. Navas, P. Artuch, R. Jou, C. Jimenez-Mallebrera, C. Nascimento, A. Pérez-Dueñas, B. Ortez, C. Ramos, F. Colomer, J. O''Callaghan, M. Pineda, M. García-Cazorla, A. Espinós, C. Ruiz, A. Macaya, A. Marcé-Grau, A. Garcia-Villoria, J. Arias, A. Emperador, S. (orcid)0000-0001-5964-6138 Ruiz-Pesini, E. Universidad de Zaragoza (orcid)0000-0002-0269-7337 Lopez-Gallardo, E. Universidad de Zaragoza (orcid)0000-0002-3217-1424 Neergheen, V. Simões, M. Diogo, L. Blázquez, A. González-Quintana, A. Delmiro, A. Domínguez-González, C. Arenas, J. García-Silva, M. T. Martín, E. Quijada, P. Hernández-Laín, A. Morán, M. Rivas Infante, E. Ávila Polo, R. Paradas Lópe, C. Bautista Lorite, J. Martínez Fernández, E. M. Cortés, A. B. Sánchez-Cuesta, A. Cascajo, M. V. Alcázar, M. Brea-Calvo, G. 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 30 (2016), 51-58 Mitochondrion MITOCHONDRION 1567-7249 156942 http://zaguan.unizar.es/record/130565/files/texto_completo.pdf Versión publicada 2658335 http://zaguan.unizar.es/record/130565/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130565 articulos driver 2024-01-26-18:10:20 ARTICLE