130572 20240126184244.0 doi 10.1111/aos.13865 sideral 108172 ART-2018-108172 eng Esteban, O. Effect of mitochondrial haplogroups on ranibizumab response in neovascular age-related macular degeneration patients: a pilot study 2018 Editor, Vascular endothelial growth factor (VEGF) is necessary for the formation of new blood vessels in neovascular age-related macular degeneration (nAMD). Thus, VEGF is a target for antiangiogenic intravitreal therapy in nAMD. One of these anti-VEGF agents is ranibizumab. Besides clinical factors, certain gene variants, that have been associated with nAMD prevalence, also influence the individual’s response to ranibizumab therapy (Dedania et al. 2015). Thus, a significant association between AMD risk and mitochondrial DNA (mtDNA) genetic background (haplogroup) has been repeatedly reported (Udar et al. 2009). We hypothesized that mtDNA genotype could partially explain the individual differences in response to ranibizumab. Patients included in the study were diagnosed of nAMD and received 3 initial monthly injections of intravitreal ranibizumab (IVR) 0.5 mg in 0.05 ml followed by a flexible pro re nata period for the remaining 8 months. The decision to re-treat was based on vision loss =5 letters... info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.153 2018 OPHTHALMOLOGY 12 / 59 = 0.203 2018 Q1 T1 1.51 2018 Ophthalmology 2018 Q1 Medicine (miscellaneous) 2018 Q1 info:eu-repo/semantics/other info:eu-repo/semantics/publishedVersion Ascaso, F.J. Universidad de Zaragoza (orcid)0000-0001-9876-5850 Mateo, J. Calvo, T. Montoya, J. Universidad de Zaragoza (orcid)0000-0003-1770-6299 Ruiz-Pesini, E. Universidad de Zaragoza (orcid)0000-0002-0269-7337 1004 646 Universidad de Zaragoza Dpto. Cirugía,Ginecol.Obstetr. Área Oftalmología 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 97, 1 (2018), e133 - e134 Acta ophthamol. ACTA OPHTHALMOLOGICA 1755-375X 157423 http://zaguan.unizar.es/record/130572/files/texto_completo.pdf Versión publicada 3463241 http://zaguan.unizar.es/record/130572/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130572 articulos driver 2024-01-26-18:10:49 ARTICLE