| Página principal > Artículos > Nutraceutical composition of three pine bark extracts and their antiproliferative effect on Caco-2 cells > MARC |
000130575 001__ 130575 000130575 005__ 20240126184244.0 000130575 0247_ $$2doi$$a10.1016/j.jff.2018.07.040 000130575 0248_ $$2sideral$$a107695 000130575 037__ $$aART-2018-107695 000130575 041__ $$aeng 000130575 100__ $$aGascón, Sonia$$uUniversidad de Zaragoza 000130575 245__ $$aNutraceutical composition of three pine bark extracts and their antiproliferative effect on Caco-2 cells 000130575 260__ $$c2018 000130575 5060_ $$aAccess copy available to the general public$$fUnrestricted 000130575 5203_ $$aThe use of vegetal materials that go unused or by-products of the food industry, for the development of functional foods is very interesting. Pine bark extracts have been useful in medicine and in functional foods, yet, little is known about its antiproliferative properties. In this work, the activity of bark extracts from different Pinus species on human colorectal adenocarcinoma (Caco-2) cells was studied. All these extracts induce cell-cycle arrest and apoptosis in Caco-2 cells through alteration of the mitochondrial membrane potential, release of cytochrome c to cytoplasm and caspase 3 activation. In addition, a significant decrease in ROS generation was also observed in the presence of the extracts tested. The results obtained in this work show that these extracts could be interesting in order to elaborate functional foods and not only for improving their antioxidant properties but also for playing an important role in the treatment of colorectal carcinoma. 000130575 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A32$$9info:eu-repo/grantAgreement/EUR/INTERREG-POCTEFA/EFA 220-11-ELENA$$9info:eu-repo/grantAgreement/ES/ISCIII-CIBERObn/CB06-03-1012$$9info:eu-repo/grantAgreement/ES/MICINN/SAF2016-75441-R$$9info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/Redvalue-SOE1-PI-E0123 000130575 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000130575 590__ $$a3.197$$b2018 000130575 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b32 / 135 = 0.237$$c2018$$dQ1$$eT1 000130575 591__ $$aNUTRITION & DIETETICS$$b36 / 85 = 0.424$$c2018$$dQ2$$eT2 000130575 592__ $$a1.107$$b2018 000130575 593__ $$aFood Science$$c2018$$dQ1 000130575 593__ $$aNutrition and Dietetics$$c2018$$dQ1 000130575 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1 000130575 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000130575 700__ $$aJiménez-Moreno, Nerea 000130575 700__ $$aJiménez, Sandra 000130575 700__ $$0(orcid)0009-0001-5345-6947$$aQuero, Javier 000130575 700__ $$0(orcid)0000-0002-3595-7668$$aRodríguez-Yoldi, María Jesús$$uUniversidad de Zaragoza 000130575 700__ $$aAncín-Azpilicueta, Carmen 000130575 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología 000130575 7102_ $$11009$$2X$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Técnica. Lab. y Talleres 000130575 773__ $$g48 (2018), 420-429$$pJOURNAL OF FUNCTIONAL FOODS$$tJournal of Functional Foods$$x1756-4646 000130575 8564_ $$s2147336$$uhttps://zaguan.unizar.es/record/130575/files/texto_completo.pdf$$yPostprint 000130575 8564_ $$s1219471$$uhttps://zaguan.unizar.es/record/130575/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000130575 909CO $$ooai:zaguan.unizar.es:130575$$particulos$$pdriver 000130575 951__ $$a2024-01-26-18:11:07 000130575 980__ $$aARTICLE
El sistema ha encontrado un error mientras gestionaba su petición.
Los administradores del sistema han sido avisados.
En caso de duda, póngase en contacto con deposita@unizar.es