130575 20240126184244.0 doi 10.1016/j.jff.2018.07.040 sideral 107695 ART-2018-107695 eng Gascón, Sonia Universidad de Zaragoza Nutraceutical composition of three pine bark extracts and their antiproliferative effect on Caco-2 cells 2018 The use of vegetal materials that go unused or by-products of the food industry, for the development of functional foods is very interesting. Pine bark extracts have been useful in medicine and in functional foods, yet, little is known about its antiproliferative properties. In this work, the activity of bark extracts from different Pinus species on human colorectal adenocarcinoma (Caco-2) cells was studied. All these extracts induce cell-cycle arrest and apoptosis in Caco-2 cells through alteration of the mitochondrial membrane potential, release of cytochrome c to cytoplasm and caspase 3 activation. In addition, a significant decrease in ROS generation was also observed in the presence of the extracts tested. The results obtained in this work show that these extracts could be interesting in order to elaborate functional foods and not only for improving their antioxidant properties but also for playing an important role in the treatment of colorectal carcinoma. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/A32 info:eu-repo/grantAgreement/EUR/INTERREG-POCTEFA/EFA 220-11-ELENA info:eu-repo/grantAgreement/ES/ISCIII-CIBERObn/CB06-03-1012 info:eu-repo/grantAgreement/ES/MICINN/SAF2016-75441-R info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/Redvalue-SOE1-PI-E0123 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.197 2018 FOOD SCIENCE & TECHNOLOGY 32 / 135 = 0.237 2018 Q1 T1 NUTRITION & DIETETICS 36 / 85 = 0.424 2018 Q2 T2 1.107 2018 Food Science 2018 Q1 Nutrition and Dietetics 2018 Q1 Medicine (miscellaneous) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Jiménez-Moreno, Nerea Jiménez, Sandra Quero, Javier (orcid)0009-0001-5345-6947 Rodríguez-Yoldi, María Jesús Universidad de Zaragoza (orcid)0000-0002-3595-7668 Ancín-Azpilicueta, Carmen 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 1009 X Universidad de Zaragoza Dpto. Patología Animal Área Técnica. Lab. y Talleres 48 (2018), 420-429 JOURNAL OF FUNCTIONAL FOODS Journal of Functional Foods 1756-4646 2147336 http://zaguan.unizar.es/record/130575/files/texto_completo.pdf Postprint 1219471 http://zaguan.unizar.es/record/130575/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:130575 articulos driver 2024-01-26-18:11:07 ARTICLE