000130596 001__ 130596
000130596 005__ 20240319081006.0
000130596 0247_ $$2doi$$a10.1080/02652048.2022.2061621
000130596 0248_ $$2sideral$$a129356
000130596 037__ $$aART-2022-129356
000130596 041__ $$aeng
000130596 100__ $$0(orcid)0000-0003-1391-3725$$aRoche, Alejandro$$uUniversidad de Zaragoza
000130596 245__ $$aEvaluation of PEG-b-polycarbonates self-assemblies containing azobenzene or coumarin moieties as nanocarriers using paclitaxel as a model hydrophobic drug
000130596 260__ $$c2022
000130596 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130596 5203_ $$aThe work assesses the performance of nanocarriers from amphiphilic block copolymers with functional azobenzene or coumarin moieties for delivery of paclitaxel. Placlitaxel was encapsulated by the nanoprecipitation method. Characterisations were performed by DLS, TEM, Zeta potential and HPLC. Cell viability was investigated in HeLa and Huh-5-2-cell lines. Coumarin-containing polymeric micelles (Dh = 26 ± 2 nm, PDI = 0.28, ζ = ‒22.9 ± 3.6 mV) with 11.2 ± 0.5%w/w drug loading showed enhanced cytotoxicity in HeLa cells (IC50 < 0.02 nM) compared to free paclitaxel (IC50 = 0.17 ± 0.02 nM). Azobenzene-containing polymeric vesicles (Dh = 390 ± 20 nm, PDI = 0.24, ζ = ‒33.2 ± 5.0 mV) with a 6.8 ± 0.4%w/w drug loading showed increased cytotoxicity under 530 nm light (IC50 = 0.0114 ± 0.00033 nM) in HeLa cells due to a stimulated delivery of paclitaxel. Effectivity of these block copolymers as paclitaxel nanovectors and light stimulated release has been demonstrated.
000130596 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B25-17R$$9info:eu-repo/grantAgreement/ES/DGA/E47-17R$$9info:eu-repo/grantAgreement/ES/ISCIII/CIBERehd$$9info:eu-repo/grantAgreement/ES/ISCIII-ERDF-ESF/PI15-00663-Investing in your future$$9info:eu-repo/grantAgreement/ES/ISCIII-ERDF-ESF/PI18-00349-Investing in your future$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2017-84838-P
000130596 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000130596 590__ $$a3.9$$b2022
000130596 591__ $$aCHEMISTRY, APPLIED$$b22 / 72 = 0.306$$c2022$$dQ2$$eT1
000130596 591__ $$aPHARMACOLOGY & PHARMACY$$b102 / 278 = 0.367$$c2022$$dQ2$$eT2
000130596 591__ $$aENGINEERING, CHEMICAL$$b53 / 141 = 0.376$$c2022$$dQ2$$eT2
000130596 592__ $$a0.511$$b2022
000130596 593__ $$aOrganic Chemistry$$c2022$$dQ2
000130596 593__ $$aColloid and Surface Chemistry$$c2022$$dQ2
000130596 593__ $$aPhysical and Theoretical Chemistry$$c2022$$dQ2
000130596 593__ $$aPharmaceutical Science$$c2022$$dQ2
000130596 593__ $$aBioengineering$$c2022$$dQ3
000130596 594__ $$a6.2$$b2022
000130596 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000130596 700__ $$aMorcuende-Ventura, Violeta
000130596 700__ $$0(orcid)0000-0003-1141-5933$$aTejedor, Rosa M.$$uUniversidad de Zaragoza
000130596 700__ $$0(orcid)0000-0002-0922-5615$$aOriol, Luis$$uUniversidad de Zaragoza
000130596 700__ $$0(orcid)0000-0001-5664-1729$$aAbian, Olga$$uUniversidad de Zaragoza
000130596 700__ $$0(orcid)0000-0001-5556-2172$$aPiñol, Milagros$$uUniversidad de Zaragoza
000130596 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000130596 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000130596 773__ $$g39, 3 (2022), 276-287$$pJ. microencapsul$$tJournal of microencapsulation$$x0265-2048
000130596 8564_ $$s1361345$$uhttps://zaguan.unizar.es/record/130596/files/texto_completo.pdf$$yPostprint
000130596 8564_ $$s1171097$$uhttps://zaguan.unizar.es/record/130596/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000130596 909CO $$ooai:zaguan.unizar.es:130596$$particulos$$pdriver
000130596 951__ $$a2024-03-18-14:37:11
000130596 980__ $$aARTICLE