130596 20240319081006.0 doi 10.1080/02652048.2022.2061621 sideral 129356 ART-2022-129356 eng Roche, Alejandro Universidad de Zaragoza (orcid)0000-0003-1391-3725 Evaluation of PEG-b-polycarbonates self-assemblies containing azobenzene or coumarin moieties as nanocarriers using paclitaxel as a model hydrophobic drug 2022 Access copy available to the general public Unrestricted The work assesses the performance of nanocarriers from amphiphilic block copolymers with functional azobenzene or coumarin moieties for delivery of paclitaxel. Placlitaxel was encapsulated by the nanoprecipitation method. Characterisations were performed by DLS, TEM, Zeta potential and HPLC. Cell viability was investigated in HeLa and Huh-5-2-cell lines. Coumarin-containing polymeric micelles (Dh = 26 ± 2 nm, PDI = 0.28, ζ = ‒22.9 ± 3.6 mV) with 11.2 ± 0.5%w/w drug loading showed enhanced cytotoxicity in HeLa cells (IC50 < 0.02 nM) compared to free paclitaxel (IC50 = 0.17 ± 0.02 nM). Azobenzene-containing polymeric vesicles (Dh = 390 ± 20 nm, PDI = 0.24, ζ = ‒33.2 ± 5.0 mV) with a 6.8 ± 0.4%w/w drug loading showed increased cytotoxicity under 530 nm light (IC50 = 0.0114 ± 0.00033 nM) in HeLa cells due to a stimulated delivery of paclitaxel. Effectivity of these block copolymers as paclitaxel nanovectors and light stimulated release has been demonstrated. info:eu-repo/grantAgreement/ES/DGA/B25-17R info:eu-repo/grantAgreement/ES/DGA/E47-17R info:eu-repo/grantAgreement/ES/ISCIII/CIBERehd info:eu-repo/grantAgreement/ES/ISCIII-ERDF-ESF/PI15-00663-Investing in your future info:eu-repo/grantAgreement/ES/ISCIII-ERDF-ESF/PI18-00349-Investing in your future info:eu-repo/grantAgreement/ES/MINECO/MAT2017-84838-P info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.9 2022 CHEMISTRY, APPLIED 22 / 72 = 0.306 2022 Q2 T1 PHARMACOLOGY & PHARMACY 102 / 278 = 0.367 2022 Q2 T2 ENGINEERING, CHEMICAL 53 / 141 = 0.376 2022 Q2 T2 0.511 2022 Organic Chemistry 2022 Q2 Colloid and Surface Chemistry 2022 Q2 Physical and Theoretical Chemistry 2022 Q2 Pharmaceutical Science 2022 Q2 Bioengineering 2022 Q3 6.2 2022 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Morcuende-Ventura, Violeta Tejedor, Rosa M. Universidad de Zaragoza (orcid)0000-0003-1141-5933 Oriol, Luis Universidad de Zaragoza (orcid)0000-0002-0922-5615 Abian, Olga Universidad de Zaragoza (orcid)0000-0001-5664-1729 Piñol, Milagros Universidad de Zaragoza (orcid)0000-0001-5556-2172 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 39, 3 (2022), 276-287 J. microencapsul Journal of microencapsulation 0265-2048 1361345 http://zaguan.unizar.es/record/130596/files/texto_completo.pdf Postprint 1171097 http://zaguan.unizar.es/record/130596/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:130596 articulos driver 2024-03-18-14:37:11 ARTICLE