130602 20241125101128.0 doi 10.1039/d2py01250b sideral 132733 ART-2023-132733 eng Abad, Miriam Universidad de Zaragoza (orcid)0000-0002-8677-3316 Aqueous seeded RAFT polymerization for the preparation of self-assemblies containing nucleobase analogues 2023 Access copy available to the general public Unrestricted Self-assemblies containing the nucleobase analogue 2,6-diacylaminopyridine (DAP) have been successfully prepared for the first time by aqueous seeded RAFT polymerization in high concentrations. For this purpose, a diblock copolymer containing poly(ethylene glycol) (PEG) and DAP polymethacrylate blocks was used as a macro-chain-transfer agent (PEG124-b-PDAP9-CTA) for the polymerization of 2-hydroxypropyl methacrylate (HPMA) in water. From the systematic variation of the degree of polymerization and solid concentration, a phase diagram has been generated that correlates both variables with the morphologies of this new system. Self-assemblies have been characterized by TEM and DLS, observing morphologies from low to high order (from spherical micelles to worms and to vesicles). Self-assembly morphologies are stable for almost a year, except in the case of worms that turn into spherical micelles after a few weeks. In addition, H-bonding supramolecular functionalization of the DAP repeating units during aqueous seeded RAFT polymerization has been examined by functionalization with a cross-linker with four thymine groups. Finally, the loading and the subsequent release of Nile Red have been proven in both supramolecular cross-linked and non-cross-linked self-assemblies. info:eu-repo/grantAgreement/ES/DGA-FSE/E47-17R info:eu-repo/grantAgreement/ES/MICINN/PID2021-126132NB-I00 info:eu-repo/grantAgreement/ES/MINECO/MAT2017-84838-P info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.1 2023 POLYMER SCIENCE 27 / 95 = 0.284 2023 Q2 T1 0.969 2023 Biomedical Engineering 2023 Q1 Organic Chemistry 2023 Q1 Polymers and Plastics 2023 Q1 Bioengineering 2023 Q2 Biochemistry 2023 Q2 8.6 2023 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Nardi, Martina Oriol, Luis Universidad de Zaragoza (orcid)0000-0002-0922-5615 Piñol, Milagros Universidad de Zaragoza (orcid)0000-0001-5556-2172 Blasco, Eva 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 14, 1 (2023), 71-80 POLYMER CHEMISTRY POLYMER CHEMISTRY 1759-9954 1750219 http://zaguan.unizar.es/record/130602/files/texto_completo.pdf Postprint 2349876 http://zaguan.unizar.es/record/130602/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:130602 articulos driver 2024-11-22-11:58:16 ARTICLE