130603 20241125101131.0 doi 10.1016/j.arr.2023.101880 sideral 132657 ART-2023-132657 eng Jiménez Salvador, Irene Universidad de Zaragoza (orcid)0000-0002-1426-3958 Developmental origins of Parkinson disease: improving the rodent models 2023 Access copy available to the general public Unrestricted Numerous pesticides are inhibitors of the oxidative phosphorylation system. Oxidative phosphorylation dysfunction adversely affects neurogenesis and often accompanies Parkinson disease. Since brain development occurs mainly in the prenatal period, early exposure to pesticides could alter the development of the nervous system and increase the risk of Parkinson disease. Different rodent models have been used to confirm this hypothesis. However, more precise considerations of the selected strain, the xenobiotic, its mode of administration, and the timing of animal analysis, are necessary to resemble the model to the human clinical condition and obtain more reliable results. info:eu-repo/grantAgreement/ES/DGA/B33-20R info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón info:eu-repo/grantAgreement/ES/DGA/LMP22_21 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI21-00229 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 12.5 2023 GERIATRICS & GERONTOLOGY 3 / 74 = 0.041 2023 Q1 T1 CELL BIOLOGY 20 / 205 = 0.098 2023 Q1 T1 3.376 2023 Aging 2023 Q1 Biochemistry 2023 Q1 Neurology 2023 Q1 Molecular Biology 2023 Q1 Biotechnology 2023 Q1 19.8 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Meade, Patricia Universidad de Zaragoza (orcid)0000-0002-3587-6622 Iglesias, Eldris Bayona-Bafaluy, Pilar Universidad de Zaragoza (orcid)0000-0002-8585-6371 Ruiz Pesini, Eduardo Universidad de Zaragoza (orcid)0000-0002-0269-7337 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 86 (2023), 101880 [8 pp.] AGEING RES REV Ageing Research Reviews 1568-1637 575659 http://zaguan.unizar.es/record/130603/files/texto_completo.pdf Versión publicada 2627792 http://zaguan.unizar.es/record/130603/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:130603 articulos driver 2024-11-22-11:58:54 ARTICLE