A model for lymphocyte activation in open versus laparoscopic surgery in colorectal cancer patients in enhanced recovery after surgery (ERAS) protocols

Martínez, A.B. (Universidad de Zaragoza) ; Longás, J. (Universidad de Zaragoza) ; Ramírez, J.M. (Universidad de Zaragoza)

Resumen: Purpose Given the high mortality and morbidity associated with colon cancer worldwide and the advantages inherent to the use of the laparoscopy technique with respect to open surgery in oncological colorectal surgery, a study was de- signed to observe and compare the lymphocyte activation model between open surgery (OS) and laparoscopic surgery (LS) for this type of patient as part of an ERAS protocol. Methods A prospective study was conducted with 38 patients who underwent surgery due to colorectal disease and were included in an ERAS protocol. The patients were divided into two groups: G1 (patients who had undergone OS; n = 19) and G2 (patients who had undergone LS; n = 19). The lymphocyte activation model was studied at three times: immediately prior to surgery and on post-operative days 1 and 3 (POD0, POD1 and POD3).
Results The Th lymphocyte activation markers studied (CD25, CD69, HLADR) exhibited a significantly higher mean value on POD0 for CD69 in OS than in LS (p = 0.037) and a significantly lower mean HLADR value on POD3 for OS than for LS (p = 0.040). No statistically significant differences were observed in either the evolution or in the mean values for the intracellular cytokines studied responsible for a Th1, Th2 or Th17 response. A Th1 response pattern was observed in both OS and LS.
Conclusions The lymphocyte activation model in OS and LS is a Th1 response in both cases. The findings for the Th lym- phocyte activation markers could indicate a better preserved immunity in LS with respect to OS.

Idioma: Inglés

DOI: 10.1007/s00384-016-2731-2

Año: 2017

Publicado en: International Journal of Colorectal Disease 32, 6 (2017), 913-916
ISSN: 0179-1958

Factor impacto JCR: 2.533 (2017)

Categ. JCR: SURGERY rank: 61 / 200 = 0.305 (2017) - Q2 - T1
Categ. JCR: GASTROENTEROLOGY & HEPATOLOGY rank: 57 / 80 = 0.712 (2017) - Q3 - T3

Factor impacto SCIMAGO: 1.054 - Gastroenterology (Q2)

Tipo y forma: Comunicación congreso (Versión definitiva)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Fisiología (Dpto. Farmacología y Fisiolog.)
Área (Departamento): Área Cirugía (Dpto. Cirugía,Ginecol.Obstetr.)