000130691 001__ 130691
000130691 005__ 20240130150402.0
000130691 0247_ $$2doi$$a10.1016/j.clnesp.2016.02.017
000130691 0248_ $$2sideral$$a123720
000130691 037__ $$aART-2016-123720
000130691 041__ $$aeng
000130691 100__ $$0(orcid)0000-0002-1557-7545$$aMartinez, Ana B.$$uUniversidad de Zaragoza
000130691 245__ $$aEffect of the enhanced recovery after surgery (ERAS) protocols on the immune response in open vs laparoscopic colorectal surgery
000130691 260__ $$c2016
000130691 5203_ $$aObjectives: In this study we aimed to identify the immune response in patients undergoing colorectal cancer surgery within an ERAS protocol and to determine whether significantly different responses were found between open and laparoscopic surgery. Serious injury is quickly followed by the systemic inflammatory response syndrome, which can lead to death. Understanding the immune response of surgical patients allows modifying it according to the surgery or anaesthetic chosen. Also, the perioperative care can attenuate the stress response to surgery and enable rapid recovery.
Methods: The analysis included 38 patients undergoing elective colorectal surgery for cancer within an ERAS Protocol at the Hospital Lozano Blesa in Zaragoza (Spain). These patients were divided into two groups according to the type of surgery: open surgery (group 1, n=19) and laparoscopic surgery (group 2, n=19).
Plasma levels of CRP, haemogram, immunoglobulins and lymphocyte profile were measured at three time points: m0 (immediately before surgery), m1 (24 hours postoperatively) and m3 (72 hours postoperatively).
Results: There were no significant differences in patient characteristics between groups in terms of gender, age and BMI. Levels of CRP were significant higher in G1 at m2 and m3. The count of lymphocytes was higher in G2 at m2. However, neutrophils levels were lower in the same group. The study of T and B cells subsets showed a significant higher CD4 and CD19 levels in G2 at m2. NK cells count was significant lower in the same group at m3. There were no significant differences in the levels of immunoglobulin between groups.
Conclusion: This study demonstrates that laparoscopic surgery appears to be associated with similar immune responses compared with open surgery, considering that immune parameters vary slightly between groups. Although higher CRP levels showed a high level of injury in the open surgery group, the management of perioperative care through an ERAS protocol seemed to minimise the effect of open surgery associated to more postoperative complications. Further studies are be required in order to clarify the significance of the different levels of CD4, CD19 and CD56 found among groups.
000130691 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130691 592__ $$a0.156$$b2016
000130691 593__ $$aNutrition and Dietetics$$c2016$$dQ4
000130691 593__ $$aEndocrinology, Diabetes and Metabolism$$c2016$$dQ4
000130691 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion
000130691 700__ $$0(orcid)0000-0001-7964-1166$$aRamírez, José M.$$uUniversidad de Zaragoza
000130691 700__ $$aCalvo, Beatriz$$uUniversidad de Zaragoza
000130691 700__ $$0(orcid)0000-0003-4173-7212$$aGracia, José A.$$uUniversidad de Zaragoza
000130691 700__ $$0(orcid)0000-0003-4347-6837$$aGuillén, Julia$$uUniversidad de Zaragoza
000130691 700__ $$0(orcid)0000-0002-3647-5679$$aLongás, Javier$$uUniversidad de Zaragoza
000130691 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000130691 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000130691 7102_ $$11004$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Cirugía
000130691 773__ $$g12 (2016), e34-e35$$tClinical Nutrition ESPEN$$x2405-4577
000130691 8564_ $$s395696$$uhttps://zaguan.unizar.es/record/130691/files/texto_completo.pdf$$yVersión publicada
000130691 8564_ $$s1145936$$uhttps://zaguan.unizar.es/record/130691/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130691 909CO $$ooai:zaguan.unizar.es:130691$$particulos$$pdriver
000130691 951__ $$a2024-01-30-14:08:23
000130691 980__ $$aARTICLE