000130720 001__ 130720
000130720 005__ 20240319081031.0
000130720 0247_ $$2doi$$a10.6515/ACS.202203_38(2).20210927A
000130720 0248_ $$2sideral$$a133295
000130720 037__ $$aART-2022-133295
000130720 041__ $$aeng
000130720 100__ $$aRoteta Unceta-Barrenechea, Ana
000130720 245__ $$aCoexistence of Positive 99mTc-DPD Scintigraphy and Monoclonal Gammopathy: A Frequent Challenge
000130720 260__ $$c2022
000130720 5203_ $$aBackground
Cardiac involvement is common in amyloidosis, and the vast majority of cases of amyloid cardiomyopathy are attributed to primary amyloidosis or transthyretin amyloidosis (ATTR). Although the coexistence of scintigraphy suggestive of ATTR with monoclonal gammopathy of undetermined significance is well documented, the correct diagnosis is still challenging in non-referral centers.
Methods
We performed a retrospective study reviewing all amyloid cardiomyopathy cases diagnosed at our center over the last 5 years, and described our experience and diagnostic approach.
Results
During the last 5 years, 74 patients with positive scintigraphy were identified. Of these patients, 41 were included in this study as they had all necessary tests for a complete diagnosis. Two of these 41 patients had variant ATTR and 29 had wild-type ATTR. Ten patients had monoclonal gammopathy (24.4%), and it was consequently impossible to obtain a specific diagnosis. During follow-up, 14 patients (34.1%), five of them from the monoclonal gammopathy group, died, reflecting the severity of disease.
Conclusions
In patients with ATTR-suggestive scintigraphy, monoclonal gammopathy frequently occurs concomitantly, thus not allowing to establish a specific diagnosis. A biopsy could only be replaced by genetic testing in selected cases.
000130720 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130720 590__ $$a1.9$$b2022
000130720 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b108 / 143 = 0.755$$c2022$$dQ4$$eT3
000130720 592__ $$a0.338$$b2022
000130720 593__ $$aCardiology and Cardiovascular Medicine$$c2022$$dQ3
000130720 594__ $$a3.0$$b2022
000130720 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130720 700__ $$aMelero Polo, Jorge
000130720 700__ $$0(orcid)0000-0003-3501-0121$$aAndrés Gracia, Alejandro$$uUniversidad de Zaragoza
000130720 700__ $$aRevilla Martí, Pablo
000130720 700__ $$aMenao Guillén, Sebastian
000130720 700__ $$aLahuerta Pueyo, Carmen
000130720 700__ $$0(orcid)0000-0001-8655-9267$$aPérez-Palacios, Raquel$$uUniversidad de Zaragoza
000130720 700__ $$aMoreno Gázquez, Inmaculada
000130720 700__ $$aGracia Gutiérrez, Anyuli
000130720 700__ $$aAibar Arregui, Miguel Angel
000130720 7102_ $$11011$$2770$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Radiol. y Medicina Física
000130720 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com
000130720 773__ $$g38, 2 (2022), 169-174$$pActa Cardiologica Sinica$$tActa Cardiologica Sinica$$x1011-6842
000130720 85641 $$uhttps://www.tsoc.org.tw/upload/journal/1/20220331/acs-38-169.pdf$$zTexto completo de la revista
000130720 8564_ $$s318003$$uhttps://zaguan.unizar.es/record/130720/files/texto_completo.pdf$$yVersión publicada
000130720 8564_ $$s2485632$$uhttps://zaguan.unizar.es/record/130720/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130720 909CO $$ooai:zaguan.unizar.es:130720$$particulos$$pdriver
000130720 951__ $$a2024-03-18-17:08:23
000130720 980__ $$aARTICLE