130720 20240319081031.0 doi 10.6515/ACS.202203_38(2).20210927A sideral 133295 ART-2022-133295 eng Roteta Unceta-Barrenechea, Ana Coexistence of Positive 99mTc-DPD Scintigraphy and Monoclonal Gammopathy: A Frequent Challenge 2022 Background Cardiac involvement is common in amyloidosis, and the vast majority of cases of amyloid cardiomyopathy are attributed to primary amyloidosis or transthyretin amyloidosis (ATTR). Although the coexistence of scintigraphy suggestive of ATTR with monoclonal gammopathy of undetermined significance is well documented, the correct diagnosis is still challenging in non-referral centers. Methods We performed a retrospective study reviewing all amyloid cardiomyopathy cases diagnosed at our center over the last 5 years, and described our experience and diagnostic approach. Results During the last 5 years, 74 patients with positive scintigraphy were identified. Of these patients, 41 were included in this study as they had all necessary tests for a complete diagnosis. Two of these 41 patients had variant ATTR and 29 had wild-type ATTR. Ten patients had monoclonal gammopathy (24.4%), and it was consequently impossible to obtain a specific diagnosis. During follow-up, 14 patients (34.1%), five of them from the monoclonal gammopathy group, died, reflecting the severity of disease. Conclusions In patients with ATTR-suggestive scintigraphy, monoclonal gammopathy frequently occurs concomitantly, thus not allowing to establish a specific diagnosis. A biopsy could only be replaced by genetic testing in selected cases. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 1.9 2022 CARDIAC & CARDIOVASCULAR SYSTEMS 108 / 143 = 0.755 2022 Q4 T3 0.338 2022 Cardiology and Cardiovascular Medicine 2022 Q3 3.0 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Melero Polo, Jorge Andrés Gracia, Alejandro Universidad de Zaragoza (orcid)0000-0003-3501-0121 Revilla Martí, Pablo Menao Guillén, Sebastian Lahuerta Pueyo, Carmen Pérez-Palacios, Raquel Universidad de Zaragoza (orcid)0000-0001-8655-9267 Moreno Gázquez, Inmaculada Gracia Gutiérrez, Anyuli Aibar Arregui, Miguel Angel 1011 770 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Radiol. y Medicina Física 1001 025 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Anatom.Anatom.Patológ.Com 38, 2 (2022), 169-174 Acta Cardiologica Sinica Acta Cardiologica Sinica 1011-6842 318003 http://zaguan.unizar.es/record/130720/files/texto_completo.pdf Versión publicada 2485632 http://zaguan.unizar.es/record/130720/files/texto_completo.jpg?subformat=icon icon Versión publicada https://www.tsoc.org.tw/upload/journal/1/20220331/acs-38-169.pdf Texto completo de la revista oai:zaguan.unizar.es:130720 articulos driver 2024-03-18-17:08:23 ARTICLE