130770 20240131210811.0 doi 10.1016/j.foodchem.2019.125918 sideral 115703 ART-2020-115703 eng Ubeda, Sara Universidad de Zaragoza (orcid)0000-0002-9804-8699 Migration studies and toxicity evaluation of cyclic polyesters oligomers from food packaging adhesives 2020 Multilayer materials used in food packaging are commonly manufactured with a polyurethane adhesive layer in its structure that may contain cyclic esters oligomers as potential migrants. However, little is known about their toxicity. In this work, two cyclic esters of polyurethane are evaluated in migration from 20 multilayer packaging samples. They were composed by adipic acid (AA), diethylene glycol (DEG) and isophthalic acid (IPA) and their structure was AA-DEG and AA-DEG-IPA-DEG. The concentration of these compounds in migration exceeded the maximum level established by Regulation EU/10/2011 (10 ng g-1). Bioaccessibility of both compounds was evaluated by studying gastric and intestinal digestion. The studies showed that the concentration of the compounds decreased during digestion and that their hydrolysed molecules increased. Furthermore, endocrine activity in vitro assays were performed. A weak androgen receptor antagonism was identified, whereas no arylhydrocarbon receptor activity or binding to the thyroid hormone transport protein was found. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/T53-17R info:eu-repo/grantAgreement/ES/MINECO/AGL2015-67362-P info:eu-repo/grantAgreement/ES/MINECO/BES-2016-077159 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 7.514 2020 CHEMISTRY, APPLIED 7 / 74 = 0.095 2020 Q1 T1 NUTRITION & DIETETICS 6 / 87 = 0.069 2020 Q1 T1 FOOD SCIENCE & TECHNOLOGY 7 / 143 = 0.049 2020 Q1 T1 1.772 2020 Analytical Chemistry 2020 Q1 Medicine (miscellaneous) 2020 Q1 Food Science 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Aznar, Margarita Universidad de Zaragoza (orcid)0000-0002-0759-9170 Rosenmai, Anna Kjerstine Vinggaard, Anne Marie Nerín, Cristina Universidad de Zaragoza (orcid)0000-0003-2685-5739 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 311 (2020), 125918 [10 pp.] Food chem. Food Chemistry 0308-8146 774533 http://zaguan.unizar.es/record/130770/files/texto_completo.pdf Postprint 1261737 http://zaguan.unizar.es/record/130770/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:130770 articulos driver 2024-01-31-19:19:23 ARTICLE