000130828 001__ 130828
000130828 005__ 20240131210811.0
000130828 0247_ $$2doi$$a10.1007/s11739-016-1517-4
000130828 0248_ $$2sideral$$a95985
000130828 037__ $$aART-2017-95985
000130828 041__ $$aeng
000130828 100__ $$0(orcid)0000-0002-3132-2171$$aDíez-Manglano, Jesús$$uUniversidad de Zaragoza
000130828 245__ $$aOral anticoagulation in patients with atrial fibrillation and medical non-neoplastic disease in a terminal stage
000130828 260__ $$c2017
000130828 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130828 5203_ $$aMany patients with non-neoplastic disease develop atrial fibrillation in advanced stages of their disease. The aim of this study is to determine the factors associated with the use of oral anticoagulants in patients with atrial fibrillation and non-neoplastic medical disease in a terminal stage, and whether their use is associated with a longer survival. Design is prospective, observational, multicentre study. Patients with atrial fibrillation and non-neoplastic disease (severe not reversible organ insufficiency) in a terminal stage were included between February 2009 and September 2010. A 6-month follow-up was carried out. We included 314 patients with a mean (SD) age of 82.6 (7.0) years. Their mean (SD) scores in CHADS2 and ATRIA scales were 3.4 (1.2) and 4.7 (2.0), respectively. Anticoagulants were prescribed to 112 (37.5 %) patients. The use of anticoagulants was associated with age (OR 0.96 95 % CI 0.93–0.99, p = 0.046) and to the Barthel index (OR 1.01 95 % CI 1.00–1.02; p = 0.034). After performing a propensity score matching analysis, 262 patients were included in the survival analysis. After 6 months, 133 (50.8 %) patients were dead. The mortality is higher among patients who are not treated with oral anticoagulants (57.1 vs. 39.4 %; p = 0.006), but it is independently associated only with the Barthel index score (HR 0.99 95 % CI 0.98–1.00; p = 0.039), delirium (HR 1.60, 95 % CI 1.08–2.36; p = 0.018), anorexia (HR 1.58 95 % CI 1.05–2.38; p = 0.027), and with the use of calcium channel blockers (HR 0.50 95 % CI 0.30–0.84; p = 0.009). In patients with atrial fibrillation and non-neoplastic disease in a terminal stage, the use of oral anticoagulants is not independently associated with a higher probability of survival.
000130828 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130828 590__ $$a2.453$$b2017
000130828 591__ $$aMEDICINE, GENERAL & INTERNAL$$b41 / 154 = 0.266$$c2017$$dQ2$$eT1
000130828 592__ $$a0.735$$b2017
000130828 593__ $$aEmergency Medicine$$c2017$$dQ1
000130828 593__ $$aInternal Medicine$$c2017$$dQ2
000130828 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000130828 700__ $$aBernabeu-Wittel, M.
000130828 700__ $$aMurcia-Zaragoza, J.
000130828 700__ $$aEscolano-Fernández, B.
000130828 700__ $$aJarava-Rol, G.
000130828 700__ $$aHernández-Quiles, C.
000130828 700__ $$aOliver, M.
000130828 700__ $$aSanz-Baena, S.
000130828 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000130828 773__ $$g12 (2017), 53-61$$pInternal and Emergency Medicine$$tInternal and Emergency Medicine$$x1828-0447
000130828 8564_ $$s737385$$uhttps://zaguan.unizar.es/record/130828/files/texto_completo.pdf$$yPostprint
000130828 8564_ $$s1683501$$uhttps://zaguan.unizar.es/record/130828/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000130828 909CO $$ooai:zaguan.unizar.es:130828$$particulos$$pdriver
000130828 951__ $$a2024-01-31-19:24:27
000130828 980__ $$aARTICLE