000130851 001__ 130851
000130851 005__ 20240912131720.0
000130851 0247_ $$2doi$$a10.1016/j.jelectrocard.2015.04.002
000130851 0248_ $$2sideral$$a91630
000130851 037__ $$aART-2015-91630
000130851 041__ $$aeng
000130851 100__ $$0(orcid)0000-0003-4130-5866$$aRamírez, Julia
000130851 245__ $$aAutomatic SVM classification of sudden cardiac death and pump failure death from autonomic and repolarization ECG markers
000130851 260__ $$c2015
000130851 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130851 5203_ $$aBackground
Considering the rates of sudden cardiac death (SCD) and pump failure death (PFD) in chronic heart failure (CHF) patients and the cost-effectiveness of their preventing treatments, identification of CHF patients at risk is an important challenge. In this work, we studied the prognostic performance of the combination of an index potentially related to dispersion of repolarization restitution (Δα), an index quantifying T-wave alternans (IAA) and the slope of heart rate turbulence (TS) for classification of SCD and PFD.
Methods
Holter ECG recordings of 597 CHF patients with sinus rhythm enrolled in the MUSIC study were analyzed and Δα, IAA and TS were obtained. A strategy was implemented using support vector machines (SVM) to classify patients in three groups: SCD victims, PFD victims and other patients (the latter including survivors and victims of non-cardiac causes). Cross-validation was used to evaluate the performance of the implemented classifier.
Results
Δα and IAA, dichotomized at 0.035 (dimensionless) and 3.73 μV, respectively, were the ECG markers most strongly associated with SCD, while TS, dichotomized at 2.5 ms/RR, was the index most strongly related to PFD. When separating SCD victims from the rest of patients, the individual marker with best performance was Δα ≥ 0.035, which, for a fixed specificity (Sp) of 90%, showed a sensitivity (Se) value of 10%, while the combination of Δα and IAA increased Se to 18%. For separation of PFD victims from the rest of patients, the best individual marker was TS ≤ 2.5 ms/RR, which, for Sp = 90%, showed a Se of 26%, this value being lower than Se = 34%, produced by the combination of Δα and TS. Furthermore, when performing SVM classification into the three reported groups, the optimal combination of risk markers led to a maximum Sp of 79% (Se = 18%) for SCD and Sp of 81% (Se = 14%) for PFD.
Conclusions
The results shown in this work suggest that it is possible to efficiently discriminate SCD and PFD in a population of CHF patients using ECG-derived risk markers like Δα, TS and IAA.
000130851 536__ $$9info:eu-repo/grantAgreement/ES/DGA/FSE$$9info:eu-repo/grantAgreement/ES/DGA/Grupo Consolidado BSICoS$$9info:eu-repo/grantAgreement/ES/MINECO/TEC2013-42140-R$$9info:eu-repo/grantAgreement/ES/MINECO/TIN2013-41998-R
000130851 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000130851 590__ $$a1.29$$b2015
000130851 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b93 / 124 = 0.75$$c2015$$dQ3$$eT3
000130851 592__ $$a0.559$$b2015
000130851 593__ $$aCardiology and Cardiovascular Medicine$$c2015$$dQ2
000130851 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000130851 700__ $$0(orcid)0000-0001-5343-5671$$aMonasterio, Violeta
000130851 700__ $$aMincholé, Ana
000130851 700__ $$aLlamedo, Mariano
000130851 700__ $$aLenis, Gustavo
000130851 700__ $$aCygankiewicz, Iwona
000130851 700__ $$aBayés de Luna, Antonio
000130851 700__ $$aMalik, Marek
000130851 700__ $$0(orcid)0000-0002-7503-3339$$aMartínez, Juan Pablo$$uUniversidad de Zaragoza
000130851 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, Pablo$$uUniversidad de Zaragoza
000130851 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza
000130851 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000130851 773__ $$g48, 4 (2015), 551-557$$pJ. electrocardiol.$$tJOURNAL OF ELECTROCARDIOLOGY$$x0022-0736
000130851 85641 $$uhttps://www.sciencedirect.com/science/article/pii/S0022073615001090?via%3Dihub$$zTexto completo de la revista
000130851 8564_ $$s141301$$uhttps://zaguan.unizar.es/record/130851/files/texto_completo.pdf$$yPostprint
000130851 8564_ $$s2615852$$uhttps://zaguan.unizar.es/record/130851/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000130851 909CO $$ooai:zaguan.unizar.es:130851$$particulos$$pdriver
000130851 951__ $$a2024-09-12-13:15:34
000130851 980__ $$aARTICLE