000130891 001__ 130891
000130891 005__ 20240201151019.0
000130891 0247_ $$2doi$$a10.1016/j.cej.2021.128472
000130891 0248_ $$2sideral$$a122353
000130891 037__ $$aART-2021-122353
000130891 041__ $$aeng
000130891 100__ $$0(orcid)0000-0003-3641-1568$$aBergua, F.$$uUniversidad de Zaragoza
000130891 245__ $$aHydrophobic eutectic solvents: Thermophysical study and application in removal of pharmaceutical products from water
000130891 260__ $$c2021
000130891 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130891 5203_ $$aExposure to persistent contaminants presents a risk to humans and animals. Specifically, the occurrence of drugs in aqueous ecosystems is related to the increase in antimicrobial resistance. Several methods to remove them have been studied but most have cost and toxicity drawbacks. Thus, the study of new eco-sustainable procedures is needed as the liquid–liquid extraction with hydrophobic solvents (ESs). In this study, we prepared six ESs mixtures with thymol (Thy) and octanoic acid (Oct) or decanoic acid (Dec) and evaluated their extractive ability in aqueous mixtures of quercetin (Q), nitrofurantoin (NF), or tetracycline (TC). In addition, we measured, correlated, and modelled both the solid–liquid equilibria of the two systems and seven thermophysical properties of the mixtures. From these calculations, we obtained the melting enthalpies of the eutectic points, isobaric thermal expansibilities, intermolecular free lengths, orientational dipolar parameters, thermodynamic properties of the surface, critical temperatures, and activation energies of viscous flow. The perturbed chain statistical associating fluid theory was found to be suitable for predicting the thermodynamic behaviour of these systems. Next, we determined the solubility of the three drugs both in water and in the eutectic mixtures, as well as the efficiency extraction (EE) of the latter. We obtained the highest extraction efficiency for the equimolar [Thy:Oct] mixture, which was the most polar solvent. The values were: EEQ=97.8%, EENF=84.9%, and EETC=95.0%. Further, performing the procedure with three cycles increased these values above 99%. The results showed the highest hydrophobicity for quercetin and the lowest for nitrofurantoin.
000130891 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E31-17R
000130891 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000130891 590__ $$a16.744$$b2021
000130891 591__ $$aENGINEERING, ENVIRONMENTAL$$b2 / 54 = 0.037$$c2021$$dQ1$$eT1
000130891 591__ $$aENGINEERING, CHEMICAL$$b4 / 142 = 0.028$$c2021$$dQ1$$eT1
000130891 592__ $$a2.419$$b2021
000130891 593__ $$aChemical Engineering (miscellaneous)$$c2021$$dQ1
000130891 593__ $$aIndustrial and Manufacturing Engineering$$c2021$$dQ1
000130891 593__ $$aChemistry (miscellaneous)$$c2021$$dQ1
000130891 594__ $$a19.4$$b2021
000130891 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000130891 700__ $$0(orcid)0000-0002-9687-4903$$aCastro, M.$$uUniversidad de Zaragoza
000130891 700__ $$0(orcid)0000-0002-8354-7436$$aMuñoz-Embid, J.$$uUniversidad de Zaragoza
000130891 700__ $$0(orcid)0000-0003-3632-6822$$aLafuente, C.$$uUniversidad de Zaragoza
000130891 700__ $$0(orcid)0000-0003-1810-9488$$aArtal, M.$$uUniversidad de Zaragoza
000130891 7102_ $$12012$$2755$$aUniversidad de Zaragoza$$bDpto. Química Física$$cÁrea Química Física
000130891 7102_ $$15001$$2065$$aUniversidad de Zaragoza$$bDpto. Ciencia Tecnol.Mater.Fl.$$cÁrea Cienc.Mater. Ingen.Metal.
000130891 773__ $$g411 (2021), 128472 [13 pp]$$pChem. eng. j.$$tChemical Engineering Journal$$x1385-8947
000130891 8564_ $$s766868$$uhttps://zaguan.unizar.es/record/130891/files/texto_completo.pdf$$yVersión publicada
000130891 8564_ $$s2549096$$uhttps://zaguan.unizar.es/record/130891/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000130891 909CO $$ooai:zaguan.unizar.es:130891$$particulos$$pdriver
000130891 951__ $$a2024-02-01-14:38:44
000130891 980__ $$aARTICLE