000130966 001__ 130966
000130966 005__ 20240202151703.0
000130966 0247_ $$2doi$$a10.1021/acs.inorgchem.9b03334
000130966 0248_ $$2sideral$$a117309
000130966 037__ $$aART-2020-117309
000130966 041__ $$aeng
000130966 100__ $$aGascón, Elena
000130966 245__ $$a(Amino)cyclophosphazenes as Multisite Ligands for the Synthesis of Antitumoral and Antibacterial Silver(I) Complexes
000130966 260__ $$c2020
000130966 5060_ $$aAccess copy available to the general public$$fUnrestricted
000130966 5203_ $$aThe reactivity of the multisite (amino)cyclotriphosphazene ligands, [N3P3(NHCy)6] and [N3P3(NHCy)3(NMe2)3], has been explored in order to obtain silver(I) metallophosphazene complexes. Two series of cationic silver(I) metallophosphazenes were obtained and characterized: [N3P3(NHCy)6{AgL}n](TfO)n [n = 2, L = PPh3 (2), PPh2Me (4); n = 3, L = PPh3 (3), PPh2Me (5), TPA (TPA = 1, 3, 5-triaza-7-phosphaadamantane, 6)] and nongem-trans-[N3P3(NHCy)3(NMe2)3{AgL}n](TfO)n [n = 2, L = PPh3 (7), PPh2Me (9); n = 3, L = PPh3 (8), PPh2Me (10)]. 5, 7, and 9 have also been characterized by single-crystal X-ray diffraction, thereby allowing key bonding information to be obtained. Compounds 2-6, 9, and 10 were screened for in vitro cytotoxic activity against two tumor human cell lines, MCF7 (breast adenocarcinoma) and HepG2 (hepatocellular carcinoma), and for antimicrobial activity against five bacterial species including Gram-positive, Gram-negative, and Mycobacteria strains. Both the IC50 and MIC values revealed excellent biological activity for these metal complexes, compared with their precursors and cisplatin and also AgNO3 and silver sulfadiazine, respectively. Both IC50 and MIC values are among the lowest values found for any silver derivatives against the cell lines and bacterial strains used in this work. The structure-activity relationships were clear. The most cytotoxic and antimicrobial derivatives were those with the triphenylphosphane and [N3P3(NHCy)6] ligands. A significant improvement in the activity was also observed upon a rise in the number of silver atoms linked to the phosphazene ring.
000130966 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B25-17R$$9info:eu-repo/grantAgreement/ES/DGA/E47-17R$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2017-84838-P
000130966 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000130966 590__ $$a5.165$$b2020
000130966 591__ $$aCHEMISTRY, INORGANIC & NUCLEAR$$b5 / 45 = 0.111$$c2020$$dQ1$$eT1
000130966 592__ $$a1.348$$b2020
000130966 593__ $$aChemistry (miscellaneous)$$c2020$$dQ1
000130966 593__ $$aPhysical and Theoretical Chemistry$$c2020$$dQ1
000130966 593__ $$aInorganic Chemistry$$c2020$$dQ1
000130966 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000130966 700__ $$aMaisanaba, Sara
000130966 700__ $$0(orcid)0000-0003-1027-7583$$aOtal, Isabel$$uUniversidad de Zaragoza
000130966 700__ $$aValero, Eva
000130966 700__ $$aRepetto, Guillermo
000130966 700__ $$aJones, Peter G.
000130966 700__ $$0(orcid)0000-0002-3444-0851$$aJiménez, Josefina$$uUniversidad de Zaragoza
000130966 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000130966 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000130966 773__ $$g59, 4 (2020), 2464-2483$$pInorg. chem.$$tInorganic Chemistry$$x0020-1669
000130966 8564_ $$s1857592$$uhttps://zaguan.unizar.es/record/130966/files/texto_completo.pdf$$yPostprint
000130966 8564_ $$s1618180$$uhttps://zaguan.unizar.es/record/130966/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000130966 909CO $$ooai:zaguan.unizar.es:130966$$particulos$$pdriver
000130966 951__ $$a2024-02-02-14:49:49
000130966 980__ $$aARTICLE