131116 20241125101136.0 doi 10.1016/j.mbs.2023.109088 sideral 136706 ART-2023-136706 eng Barrio, R. Universidad de Zaragoza (orcid)0000-0002-8089-343X Mathematical birth of early afterdepolarizations in a cardiomyocyte model 2023 Access copy available to the general public Unrestricted Early Afterdepolarizations (EADs) are abnormal behaviors that can lead to cardiac failure and even cardiac death. In this paper we investigate the occurrence and development of these phenomena in a reduced Luo–Rudy cardiac model. Through a comprehensive dynamical analysis, we map out the distinct patterns observed in the parametric plane, differentiating between normal beats without EADs and pathological beats with EADs. By examining the bifurcation structure of the model, we elucidate the dynamical elements associated with these patterns and their transitions. Using a fast–slow analysis, we explore the emergence and evolution of EADs in the model. Notably, our approach combines the two commonly used fast–slow approaches (1-slow–2-fast and 2-slow–1-fast), and we show how both approaches together provide a more complete understanding of this phenomenon. info:eu-repo/grantAgreement/ES/AEI/PID2021-122961NB-I00 info:eu-repo/grantAgreement/ES/DGA-FSE/E24-20R info:eu-repo/grantAgreement/ES/DGA/LMP94_21 info:eu-repo/grantAgreement/ES/MICINN-AEI/PID2020-113052GB-I00 info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00 info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 1.9 2023 BIOLOGY 52 / 109 = 0.477 2023 Q2 T2 MATHEMATICAL & COMPUTATIONAL BIOLOGY 37 / 66 = 0.561 2023 Q3 T2 0.639 2023 Agricultural and Biological Sciences (miscellaneous) 2023 Q1 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2023 Q2 Statistics and Probability 2023 Q2 Medicine (miscellaneous) 2023 Q2 Modeling and Simulation 2023 Q2 Applied Mathematics 2023 Q2 Immunology and Microbiology (miscellaneous) 2023 Q2 7.5 2023 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Jover-Galtier, J.A. Universidad de Zaragoza (orcid)0000-0001-9868-9368 Martínez, M.A. Universidad de Zaragoza (orcid)0000-0002-7374-3222 Pérez, L. Serrano, S. Universidad de Zaragoza (orcid)0000-0002-5701-1670 2005 595 Universidad de Zaragoza Dpto. Matemática Aplicada Área Matemática Aplicada 366 (2023), 109088 [13 pp.] Math. biosci. MATHEMATICAL BIOSCIENCES 0025-5564 5719055 http://zaguan.unizar.es/record/131116/files/texto_completo.pdf Versión publicada 2562243 http://zaguan.unizar.es/record/131116/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:131116 articulos driver 2024-11-22-12:01:07 ARTICLE