000131136 001__ 131136 000131136 005__ 20240205173707.0 000131136 0247_ $$2doi$$a10.1371/journal.pone.0022178 000131136 0248_ $$2sideral$$a73864 000131136 037__ $$aART-2011-73864 000131136 041__ $$aeng 000131136 100__ $$0(orcid)0000-0002-2980-9685$$aSanz, J. 000131136 245__ $$aThe transcriptional regulatory network of mycobacterium tuberculosis 000131136 260__ $$c2011 000131136 5060_ $$aAccess copy available to the general public$$fUnrestricted 000131136 5203_ $$aUnder the perspectives of network science and systems biology, the characterization of transcriptional regulatory (TR) networks beyond the context of model organisms offers a versatile tool whose potential remains yet mainly unexplored. In this work, we present an updated version of the TR network of Mycobacterium tuberculosis (M.tb), which incorporates newly characterized transcriptional regulations coming from 31 recent, different experimental works available in the literature. As a result of the incorporation of these data, the new network doubles the size of previous data collections, incorporating more than a third of the entire genome of the bacterium. We also present an exhaustive topological analysis of the new assembled network, focusing on the statistical characterization of motifs significances and the comparison with other model organisms. The expanded M.tb transcriptional regulatory network, considering its volume and completeness, constitutes an important resource for diverse tasks such as dynamic modeling of gene expression and signaling processes, computational reliability determination or protein function prediction, being the latter of particular relevance, given that the function of only a small percent of the proteins of M.tb is known. 000131136 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000131136 590__ $$a4.092$$b2011 000131136 591__ $$aBIOLOGY$$b12 / 85 = 0.141$$c2011$$dQ1$$eT1 000131136 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000131136 700__ $$0(orcid)0000-0001-6148-0667$$aNavarro, J. 000131136 700__ $$0(orcid)0000-0002-3377-4171$$aArbués, A.$$uUniversidad de Zaragoza 000131136 700__ $$0(orcid)0000-0003-2993-5478$$aMartín, C.$$uUniversidad de Zaragoza 000131136 700__ $$aMarijuán, P. C. 000131136 700__ $$0(orcid)0000-0002-0895-1893$$aMoreno, Y.$$uUniversidad de Zaragoza 000131136 7102_ $$11008$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Microbiología 000131136 7102_ $$12004$$2405$$aUniversidad de Zaragoza$$bDpto. Física Teórica$$cÁrea Física Teórica 000131136 773__ $$g6, 7 (2011), e22178 [9 pp]$$pPLoS One$$tPLoS ONE$$x1932-6203 000131136 8564_ $$s426517$$uhttps://zaguan.unizar.es/record/131136/files/texto_completo.pdf$$yVersión publicada 000131136 8564_ $$s3224921$$uhttps://zaguan.unizar.es/record/131136/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000131136 909CO $$ooai:zaguan.unizar.es:131136$$particulos$$pdriver 000131136 951__ $$a2024-02-05-15:07:07 000131136 980__ $$aARTICLE