131136 20240205173707.0 doi 10.1371/journal.pone.0022178 sideral 73864 ART-2011-73864 eng Sanz, J. (orcid)0000-0002-2980-9685 The transcriptional regulatory network of mycobacterium tuberculosis 2011 Under the perspectives of network science and systems biology, the characterization of transcriptional regulatory (TR) networks beyond the context of model organisms offers a versatile tool whose potential remains yet mainly unexplored. In this work, we present an updated version of the TR network of Mycobacterium tuberculosis (M.tb), which incorporates newly characterized transcriptional regulations coming from 31 recent, different experimental works available in the literature. As a result of the incorporation of these data, the new network doubles the size of previous data collections, incorporating more than a third of the entire genome of the bacterium. We also present an exhaustive topological analysis of the new assembled network, focusing on the statistical characterization of motifs significances and the comparison with other model organisms. The expanded M.tb transcriptional regulatory network, considering its volume and completeness, constitutes an important resource for diverse tasks such as dynamic modeling of gene expression and signaling processes, computational reliability determination or protein function prediction, being the latter of particular relevance, given that the function of only a small percent of the proteins of M.tb is known. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.092 2011 BIOLOGY 12 / 85 = 0.141 2011 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Navarro, J. (orcid)0000-0001-6148-0667 Arbués, A. Universidad de Zaragoza (orcid)0000-0002-3377-4171 Martín, C. Universidad de Zaragoza (orcid)0000-0003-2993-5478 Marijuán, P. C. Moreno, Y. Universidad de Zaragoza (orcid)0000-0002-0895-1893 1008 630 Universidad de Zaragoza Dpto. Microb.Med.Pr.,Sal.Públ. Área Microbiología 2004 405 Universidad de Zaragoza Dpto. Física Teórica Área Física Teórica 6, 7 (2011), e22178 [9 pp] PLoS One PLoS ONE 1932-6203 426517 http://zaguan.unizar.es/record/131136/files/texto_completo.pdf Versión publicada 3224921 http://zaguan.unizar.es/record/131136/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:131136 articulos driver 2024-02-05-15:07:07 ARTICLE