000131152 001__ 131152
000131152 005__ 20240206154529.0
000131152 0247_ $$2doi$$a10.1007/s10439-015-1426-0
000131152 0248_ $$2sideral$$a92226
000131152 037__ $$aART-2016-92226
000131152 041__ $$aeng
000131152 100__ $$0(orcid)0000-0002-6773-6667$$aAriza-Gracia, M.Á.$$uUniversidad de Zaragoza
000131152 245__ $$aAutomatized patient-specific methodology for numerical determination of biomechanical corneal response
000131152 260__ $$c2016
000131152 5060_ $$aAccess copy available to the general public$$fUnrestricted
000131152 5203_ $$aThis work presents a novel methodology for building a three-dimensional patient-specific eyeball model suitable for performing a fully automatic finite element (FE) analysis of the corneal biomechanics. The reconstruction algorithm fits and smooths the patient’s corneal surfaces obtained in clinic with corneal topographers and creates an FE mesh for the simulation. The patient’s corneal elevation and pachymetry data is kept where available, to account for all corneal geometric features (central corneal thickness–CCT and curvature). Subsequently, an iterative free-stress algorithm including a fiber’s pull-back is applied to incorporate the pre-stress field to the model. A convergence analysis of the mesh and a sensitivity analysis of the parameters involved in the numerical response is also addressed to determine the most influential features of the FE model. As a final step, the methodology is applied on the simulation of a general non-commercial non-contact tonometry diagnostic test over a large set of 130 patients—53 healthy, 63 keratoconic (KTC) and 14 post-LASIK surgery eyes. Results show the influence of the CCT, intraocular pressure (IOP) and fibers (87%) on the numerical corneal displacement (Formula presented.) the good agreement of the (Formula presented.) with clinical results, and the importance of considering the corneal pre-stress in the FE analysis. The potential and flexibility of the methodology can help improve understanding of the eye biomechanics, to help to plan surgeries, or to interpret the results of new diagnosis tools (i.e., non-contact tonometers).
000131152 536__ $$9info:eu-repo/grantAgreement/EC/FP7/606634/EU/Development of corneal biomechanical model. Dynamic topographical characterization based on 3D plenoptic imaging/POPCORN$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2011-27939-C02-01$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2014-54981-R
000131152 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000131152 590__ $$a3.221$$b2016
000131152 591__ $$aENGINEERING, BIOMEDICAL$$b18 / 77 = 0.234$$c2016$$dQ1$$eT1
000131152 592__ $$a1.096$$b2016
000131152 593__ $$aBiomedical Engineering$$c2016$$dQ1
000131152 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000131152 700__ $$aZurita, J.
000131152 700__ $$aPiñero, D.P.
000131152 700__ $$0(orcid)0000-0001-9713-1813$$aCalvo, B.$$uUniversidad de Zaragoza
000131152 700__ $$0(orcid)0000-0001-7612-266X$$aRodríguez-Matas, J.F.$$uUniversidad de Zaragoza
000131152 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000131152 773__ $$g44, 5 (2016), 1753–1772$$pAnn. biomed. eng.$$tAnnals of Biomedical Engineering$$x0090-6964
000131152 8564_ $$s3048153$$uhttps://zaguan.unizar.es/record/131152/files/texto_completo.pdf$$yPostprint
000131152 8564_ $$s1458886$$uhttps://zaguan.unizar.es/record/131152/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000131152 909CO $$ooai:zaguan.unizar.es:131152$$particulos$$pdriver
000131152 951__ $$a2024-02-06-14:44:51
000131152 980__ $$aARTICLE