000131164 001__ 131164
000131164 005__ 20240206154529.0
000131164 0247_ $$2doi$$a10.1016/j.jchf.2018.05.015
000131164 0248_ $$2sideral$$a109016
000131164 037__ $$aART-2018-109016
000131164 041__ $$aeng
000131164 100__ $$aAlmendro-Delia, M.
000131164 245__ $$aShort- and Long-Term Prognostic Relevance of Cardiogenic Shock in Takotsubo Syndrome: Results From the RETAKO Registry
000131164 260__ $$c2018
000131164 5203_ $$aObjectives: This study sought to describe the incidence, determinants, and prognostic impact of cardiogenic shock (CS) in takotsubo syndrome (TTS). Background: TTS can be associated with severe hemodynamic instability. The prognostic implication of CS has not been well characterized in large studies of TTS. Methods: We analyzed patients with a definitive TTS diagnosis (modified Mayo criteria) who were recruited for the National RETAKO (Registry on Takotsubo Syndrome) trial from 2003 to 2016. Cox and competing risk regression models were used to identify factors associated with mortality and recurrences. Results: A total of 711 patients were included, 81 (11.4%) of whom developed CS. Male sex, QTc interval prolongation, lower left ventricular ejection fraction at admission, physical triggers, and presence of “a significant” left intraventricular pressure gradient, were associated with CS (C index = 0.85). In-hospital complication rates, including mortality, were significantly higher in patients with CS. Over a median follow-up of 284 days (interquartile range: 94 to 929 days), CS was the strongest independent predictor of long-term, all-cause mortality (hazard ratio [HR]: 5.38; 95% confidence interval [CI]: 2.60 to 8.38); cardiovascular (CV) death (sub-HR: 4.29; 95% CI: 2.40 to 21.2), and non-CV death (sub-HR: 3.34; 95% CI: 1.70 to 6.53), whereas no significant difference in the recurrence rate was observed between groups (sub-HR: 0.76; 95% CI: 0.10 to 5.95). Among patients with CS, those who received beta-blockers at hospital discharge experienced lower 1-year mortality compared with those who did not receive a beta-blocker (HR: 0.52; 95% CI: 0.44 to 0.79; pinteraction = 0.043). Conclusions: CS is not uncommon and is associated with worse short- and long-term prognosis in TTS. CS complicating TTS may constitute a marker of underlying disease severity and could identify a masked heart failure phenotype with increased vulnerability to catecholamine-mediated myocardial stunning.
000131164 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000131164 590__ $$a8.91$$b2018
000131164 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b10 / 135 = 0.074$$c2018$$dQ1$$eT1
000131164 592__ $$a4.642$$b2018
000131164 593__ $$aCardiology and Cardiovascular Medicine$$c2018$$dQ1
000131164 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131164 700__ $$aNúñez-Gil, I.J.
000131164 700__ $$aLobo, M.
000131164 700__ $$aAndrés, M.
000131164 700__ $$aVedia, O.
000131164 700__ $$aSionis, A.
000131164 700__ $$aMartin-García, A.
000131164 700__ $$aCruz Aguilera, M.
000131164 700__ $$aPereyra, E.
000131164 700__ $$aMartín de Miguel, I.
000131164 700__ $$0(orcid)0000-0002-4236-6954$$aLinares Vicente, J.A.$$uUniversidad de Zaragoza
000131164 700__ $$aCorbí-Pascual, M.
000131164 700__ $$aBosch, X.
000131164 700__ $$aFabregat Andrés, O.
000131164 700__ $$aSánchez Grande Flecha, A.
000131164 700__ $$aPérez-Castellanos, A.
000131164 700__ $$aPais, J.L.
000131164 700__ $$aDe Mora Martín, M.
000131164 700__ $$aEscudier Villa, J.M.
000131164 700__ $$aMartín Asenjo, R.
000131164 700__ $$aGuillen Marzo, M.
000131164 700__ $$aRueda Sobella, F.
000131164 700__ $$aAceña, Á.
000131164 700__ $$aGarcía Acuña, J.M.
000131164 700__ $$aGarcía-Rubira, J.C.
000131164 700__ $$aFigueras, J.
000131164 700__ $$aBarrabes, J.A.
000131164 700__ $$aAndrés, M.
000131164 700__ $$aNúñez Gil, I.J.
000131164 700__ $$aMejía, H.D.
000131164 700__ $$aVedia, O.
000131164 700__ $$aFeltes, G.
000131164 700__ $$aWorner, F.
000131164 700__ $$aBascompte Claret, R.
000131164 700__ $$aPereyra, E.
000131164 700__ $$aJiménez Candil, J.
000131164 700__ $$aGarcía Sánchez, M.J.
000131164 700__ $$aMartín García, A.C.
000131164 700__ $$aMartín García, A.
000131164 700__ $$aBodi, V.
000131164 700__ $$aBonanad, C.
000131164 700__ $$aBastante, T.
000131164 700__ $$aCruz Aguilera, M.
000131164 700__ $$aPalazuelos, J.
000131164 700__ $$aSancho Carmona, D.
000131164 700__ $$aLópez Pais, J.
000131164 700__ $$aAlonso, J.J.
000131164 700__ $$aAlmendro Delia, M.
000131164 700__ $$aLobo, M.
000131164 700__ $$aRodríguez de Leiras, S.
000131164 700__ $$aGarcía Rubira, J.C.
000131164 700__ $$aCorbí-Pascual, M.
000131164 700__ $$aCórdoba Soriano, J.G.
000131164 700__ $$aDe Mora Martín, M.
000131164 700__ $$aPérez, B.
000131164 700__ $$aMartín Asensio, R.
000131164 700__ $$aRueda Sobella, F.
000131164 700__ $$aSantos Pardo, I.
000131164 700__ $$aManzano Nieto, M.C.
000131164 700__ $$aEscudier Villa, J.M.
000131164 700__ $$aFabregat Andrés, O.
000131164 700__ $$aRidocci-Soriano, F.
000131164 700__ $$aParias Ángel, M.N.
000131164 700__ $$aGaebelt, H.P.
000131164 700__ $$aAceña, A.
000131164 700__ $$aMartin Reyes, R.
000131164 700__ $$aBergua, C.
000131164 700__ $$aSanz Puértolas, P.
000131164 700__ $$aEcheverria Lucotti, I.
000131164 700__ $$aVidal Pérez, R.
000131164 700__ $$aSionis, A.
000131164 700__ $$aDuran Cambra, A.
000131164 700__ $$aTómas Ortiz, J.
000131164 700__ $$aBosch Genover, X.
000131164 700__ $$aGuillen Marzo, M.
000131164 700__ $$aBardají, R.A.
000131164 700__ $$aGarcía Acuña, J.M.
000131164 700__ $$aSánchez Grande Flecha, A.
000131164 700__ $$aGarcía González, M.J.
000131164 700__ $$aGarcía de la Villa Redondo, G.
000131164 700__ $$aPérez Castellanos, A.
000131164 700__ $$aPiqueras-Flores, J.
000131164 700__ $$aRuíz Valdepeas Herrero, L.
000131164 700__ $$aLinares Vicente, J.A.
000131164 700__ $$aRuiz Arroyo, J.R.
000131164 700__ $$aGarcía, J.
000131164 700__ $$aGiner Caro, J.A.
000131164 700__ $$aMartínez Selles, M.
000131164 700__ $$aMartín de Miguel, I.
000131164 700__ $$aRETAKO, Investigators
000131164 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000131164 773__ $$g6, 11 (2018), 928-936$$pJACC: heart failure$$tJACC-Heart Failure$$x2213-1779
000131164 8564_ $$s700081$$uhttps://zaguan.unizar.es/record/131164/files/texto_completo.pdf$$yVersión publicada
000131164 8564_ $$s2471901$$uhttps://zaguan.unizar.es/record/131164/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131164 909CO $$ooai:zaguan.unizar.es:131164$$particulos$$pdriver
000131164 951__ $$a2024-02-06-14:45:50
000131164 980__ $$aARTICLE