131269 20240207154753.0 doi 10.1016/j.jff.2018.03.002 sideral 105305 ART-2018-105305 eng Parrón, J.A. (orcid)0000-0003-4505-0418 Antirotaviral activity of bovine milk components: Extending the list of inhibitory proteins and seeking a better understanding of their neutralization mechanism 2018 The viral gastroenteritis mediated by rotavirus remains a major health problem, causing significant infant morbidity and mortality, and health care costs worldwide. Diverse studies have indicated that some milk-derived fractions exhibit antirotaviral activity, associated to proteins such as immunoglobulins, lactoferrin, mucins, and lactadherin. Nevertheless, further studies are needed to enable greater understanding of the interaction mechanisms involving rotaviruses, host cells, and neutralizing agents. Our results demonstrate that bovine milk is a source of antirotaviral compounds against a wide range of strains. The neutralizing activity of milk fractions was found to be directed to the spike protein VP4, while the purified milk proteins inhibited through interaction with either VP4 and/or VP7. The present results highlight the huge potential of bovine milk components for their inclusion in functional foods to control rotavirus diarrhea. info:eu-repo/grantAgreement/ES/CICYT/AGL2010-20835 info:eu-repo/semantics/closedAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.197 2018 FOOD SCIENCE & TECHNOLOGY 32 / 135 = 0.237 2018 Q1 T1 NUTRITION & DIETETICS 36 / 85 = 0.424 2018 Q2 T2 1.107 2018 Food Science 2018 Q1 Nutrition and Dietetics 2018 Q1 Medicine (miscellaneous) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Ripollés, D. (orcid)0000-0003-2680-7593 Sánchez, A.C. Pérez, M.D. Universidad de Zaragoza (orcid)0000-0003-2555-8425 Calvo, M. Universidad de Zaragoza (orcid)0000-0001-5373-9210 López, S. Arias, C.F. Sánchez, L. Universidad de Zaragoza (orcid)0000-0001-5964-823X 2008 780 Universidad de Zaragoza Dpto. Produc.Animal Cienc.Ali. Área Tecnología de Alimentos 44 (2018), 103-111 JOURNAL OF FUNCTIONAL FOODS Journal of Functional Foods 1756-4646 586843 http://zaguan.unizar.es/record/131269/files/texto_completo.pdf Postprint 2563399 http://zaguan.unizar.es/record/131269/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:131269 articulos driver 2024-02-07-14:36:09 ARTICLE