000131369 001__ 131369
000131369 005__ 20240208144956.0
000131369 0247_ $$2doi$$a10.3390/ijerph18189497
000131369 0248_ $$2sideral$$a125687
000131369 037__ $$aART-2021-125687
000131369 041__ $$aeng
000131369 100__ $$0(orcid)0000-0001-6025-5070$$aHernández-Vicente, Adrián$$uUniversidad de Zaragoza
000131369 245__ $$aECG ventricular repolarization dynamics during exercise: Temporal profile, relation to heart rate variability and effects of age and physical health
000131369 260__ $$c2021
000131369 5060_ $$aAccess copy available to the general public$$fUnrestricted
000131369 5203_ $$aPeriodic repolarization dynamics (PRD) is a novel electrocardiographic marker of cardiac repolarization instability with powerful risk stratification capacity for total mortality and sudden cardiac death. Here, we use a time-frequency analysis approach to continuously quantify PRD at rest and during exercise, assess its dependence on heart rate variability (HRV) and characterize the effects of age (young adults/middle-aged adults/older adults), body mass index (non-overweight/overweight) and cardiorespiratory fitness level (fit/unfit). Sixty-six male volunteers performed an exercise test. RR and dT variabilities (RRV, dTV), as well as the fraction of dT variability unrelated to RR variability, were computed based on time-frequency representations. The instantaneous LF power of dT (PdTV), representing the same concept as PRD, and of its RRV-unrelated component (PdTVuRRV) were quantified. dT angle was found to mostly oscillate in the LF band. Overall, 50-70% of PdTV was linearly unrelated to RRV. The onset of exercise caused a sudden increase in PdTV and PdTVuRRV, which returned to pre-exercise levels during recovery. Clustering analysis identified a group of overweight and unfit individuals with significantly higher PdTV and PdTVuRRV values at rest than the rest of the population. Our findings shed new light on the temporal profile of PRD during exercise, its relationship to HRV and the differences in PRD between subjects according to phenotypic characteristics. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
000131369 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/LMP24-18$$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group$$9info:eu-repo/grantAgreement/ES/DGA/LMP124-18$$9info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638284-MODELAGE$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00$$9info:eu-repo/grantAgreement/ES/MICIU/RTI2018-097723-B-I00
000131369 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000131369 590__ $$a4.614$$b2021
000131369 591__ $$aPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH$$b45 / 182 = 0.247$$c2021$$dQ1$$eT1
000131369 591__ $$aENVIRONMENTAL SCIENCES$$b100 / 279 = 0.358$$c2021$$dQ2$$eT2
000131369 591__ $$aPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH$$b71 / 210 = 0.338$$c2021$$dQ2$$eT2
000131369 592__ $$a0.814$$b2021
000131369 593__ $$aPollution$$c2021$$dQ1
000131369 593__ $$aHealth, Toxicology and Mutagenesis$$c2021$$dQ1
000131369 594__ $$a4.5$$b2021
000131369 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131369 700__ $$0(orcid)0000-0002-1462-4880$$aHernando, David
000131369 700__ $$0(orcid)0000-0002-4303-4097$$aVicente-Rodríguez, Germán$$uUniversidad de Zaragoza
000131369 700__ $$0(orcid)0000-0003-1272-0550$$aBailón, Raquel$$uUniversidad de Zaragoza
000131369 700__ $$0(orcid)0000-0001-8374-9081$$aGaratachea, Nuria$$uUniversidad de Zaragoza
000131369 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza
000131369 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor.
000131369 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000131369 773__ $$g18, 18 (2021), 9497 [20 pp.]$$pInt. j. environ. res. public health$$tInternational journal of environmental research and public health$$x1661-7827
000131369 8564_ $$s2117452$$uhttps://zaguan.unizar.es/record/131369/files/texto_completo.pdf$$yVersión publicada
000131369 8564_ $$s2746196$$uhttps://zaguan.unizar.es/record/131369/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131369 909CO $$ooai:zaguan.unizar.es:131369$$particulos$$pdriver
000131369 951__ $$a2024-02-08-14:47:41
000131369 980__ $$aARTICLE