131369 20240208144956.0 doi 10.3390/ijerph18189497 sideral 125687 ART-2021-125687 eng Hernández-Vicente, Adrián Universidad de Zaragoza (orcid)0000-0001-6025-5070 ECG ventricular repolarization dynamics during exercise: Temporal profile, relation to heart rate variability and effects of age and physical health 2021 Access copy available to the general public Unrestricted Periodic repolarization dynamics (PRD) is a novel electrocardiographic marker of cardiac repolarization instability with powerful risk stratification capacity for total mortality and sudden cardiac death. Here, we use a time-frequency analysis approach to continuously quantify PRD at rest and during exercise, assess its dependence on heart rate variability (HRV) and characterize the effects of age (young adults/middle-aged adults/older adults), body mass index (non-overweight/overweight) and cardiorespiratory fitness level (fit/unfit). Sixty-six male volunteers performed an exercise test. RR and dT variabilities (RRV, dTV), as well as the fraction of dT variability unrelated to RR variability, were computed based on time-frequency representations. The instantaneous LF power of dT (PdTV), representing the same concept as PRD, and of its RRV-unrelated component (PdTVuRRV) were quantified. dT angle was found to mostly oscillate in the LF band. Overall, 50-70% of PdTV was linearly unrelated to RRV. The onset of exercise caused a sudden increase in PdTV and PdTVuRRV, which returned to pre-exercise levels during recovery. Clustering analysis identified a group of overweight and unfit individuals with significantly higher PdTV and PdTVuRRV values at rest than the rest of the population. Our findings shed new light on the temporal profile of PRD during exercise, its relationship to HRV and the differences in PRD between subjects according to phenotypic characteristics. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. info:eu-repo/grantAgreement/ES/DGA-FSE/LMP24-18 info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group info:eu-repo/grantAgreement/ES/DGA/LMP124-18 info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638284-MODELAGE info:eu-repo/grantAgreement/ES/MICINN/PID2019-105674RB-I00 info:eu-repo/grantAgreement/ES/MICIU/RTI2018-097723-B-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.614 2021 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 45 / 182 = 0.247 2021 Q1 T1 ENVIRONMENTAL SCIENCES 100 / 279 = 0.358 2021 Q2 T2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 71 / 210 = 0.338 2021 Q2 T2 0.814 2021 Pollution 2021 Q1 Health, Toxicology and Mutagenesis 2021 Q1 4.5 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Hernando, David (orcid)0000-0002-1462-4880 Vicente-Rodríguez, Germán Universidad de Zaragoza (orcid)0000-0002-4303-4097 Bailón, Raquel Universidad de Zaragoza (orcid)0000-0003-1272-0550 Garatachea, Nuria Universidad de Zaragoza (orcid)0000-0001-8374-9081 Pueyo, Esther Universidad de Zaragoza (orcid)0000-0002-1960-407X 1006 245 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Educación Física y Depor. 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 18, 18 (2021), 9497 [20 pp.] Int. j. environ. res. public health International journal of environmental research and public health 1661-7827 2117452 http://zaguan.unizar.es/record/131369/files/texto_completo.pdf Versión publicada 2746196 http://zaguan.unizar.es/record/131369/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:131369 articulos driver 2024-02-08-14:47:41 ARTICLE