000131394 001__ 131394
000131394 005__ 20240208155436.0
000131394 0247_ $$2doi$$a10.3390/ijms25041983
000131394 0248_ $$2sideral$$a136814
000131394 037__ $$aART-2024-136814
000131394 041__ $$aeng
000131394 100__ $$aEncinas-Gimenez, Miguel$$uUniversidad de Zaragoza
000131394 245__ $$aCellular Alterations Due to Direct and Indirect Interaction of Nanomaterials with Nucleic Acids
000131394 260__ $$c2024
000131394 5060_ $$aAccess copy available to the general public$$fUnrestricted
000131394 5203_ $$aDeoxyribonucleic acid (DNA) represents the main reservoir of genetic information in the cells, which is why it is protected in the nucleus. Entry into the nucleus is, in general, difficult, as the nuclear membrane is a selective barrier to molecules longer than 40 kDa. However, in some cases, the size of certain nanoparticles (NPs) allows their internalization into the nucleus, thus causing a direct effect on the DNA structure. NPs can also induce indirect effects on DNA through reactive oxygen species (ROS) generation. In this context, nanomaterials are emerging as a disruptive tool for the development of novel therapies in a broad range of biomedical fields; although their effect on cell viability is commonly studied, further interactions with DNA or indirect alterations triggered by the internalization of these materials are not always clarified, since the small size of these materials makes them perfectly suitable for interaction with subcellular structures, such as the nucleus. In this context, and using as a reference the predicted interactions presented in a computational model, we describe and discuss the observed direct and indirect effects of the implicated nanomaterials on DNA.
000131394 536__ $$9info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE$$9info:eu-repo/grantAgreement/ES/ISCIII DTS21-00130$$9info:eu-repo/grantAgreement/ES/ISCIII/PI19-01007
000131394 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000131394 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131394 700__ $$0(orcid)0000-0003-4160-9720$$aMartin-Duque, Pilar$$uUniversidad de Zaragoza
000131394 700__ $$aMartín-Pardillos, Ana$$uUniversidad de Zaragoza
000131394 7102_ $$11013$$2275$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Estomatología
000131394 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000131394 773__ $$g25, 4 (2024), 1983 [24 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000131394 8564_ $$s1126145$$uhttps://zaguan.unizar.es/record/131394/files/texto_completo.pdf$$yVersión publicada
000131394 8564_ $$s2689483$$uhttps://zaguan.unizar.es/record/131394/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131394 909CO $$ooai:zaguan.unizar.es:131394$$particulos$$pdriver
000131394 951__ $$a2024-02-08-14:38:19
000131394 980__ $$aARTICLE