000131411 001__ 131411
000131411 005__ 20241125101139.0
000131411 0247_ $$2doi$$a10.1038/s41598-023-50537-y
000131411 0248_ $$2sideral$$a136838
000131411 037__ $$aART-2023-136838
000131411 041__ $$aeng
000131411 100__ $$aMartínez-Domínguez, Samuel J.$$uUniversidad de Zaragoza
000131411 245__ $$aUnravelling the cellular response to the SARS-COV-2 vaccine in inflammatory bowel disease patients on biologic drugs
000131411 260__ $$c2023
000131411 5060_ $$aAccess copy available to the general public$$fUnrestricted
000131411 5203_ $$aSuboptimal vaccine response is a significant concern in patients with Inflammatory Bowel Disease (IBD) receiving biologic drugs. This single-center observational study involved 754 patients with IBD. In Phase I (October 2020-April 2021), 754 IBD participants who had not previously received the SARS-CoV-2 vaccine, underwent blood extraction to assess the seroprevalence of SARS-CoV-2 infection and IBD-related factors. Phase II (May 2021-October 2021) included a subgroup of 52 IBD participants with confirmed previous SARS-CoV-2 infection, who were studied for humoral and cellular response to the SARS-CoV-2 vaccine. In Phase I, treatment with anti-TNF was associated with lower rates of seroconversion (aOR 0.25 95% CI [0.10–0.61]). In Phase II, a significant increase in post-vaccination IgG levels was observed regardless of biologic treatment. However, patients treated with anti-TNF exhibited significantly lower IgG levels compared to those without IBD therapy (5.32 ± 2.47 vs. 7.99 ± 2.59 U/ml, p = 0.042). Following vaccination, a lymphocyte, monocyte, and NK cell activation pattern was observed, with no significant differences between patients receiving biologic drugs and those without IBD treatment. Despite lower seroprevalence and humoral response to the SARS-CoV-2 vaccine in patients treated with anti-TNF, the cellular response to the vaccine did not differ significantly from that patients without IBD therapy.
000131411 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2020-113963RB-I00$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B29-17R$$9info:eu-repo/grantAgreement/ES/ISCIII/CB21-13-100087
000131411 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000131411 590__ $$a3.8$$b2023
000131411 592__ $$a0.9$$b2023
000131411 591__ $$aMULTIDISCIPLINARY SCIENCES$$b25 / 134 = 0.187$$c2023$$dQ1$$eT1
000131411 593__ $$aMultidisciplinary$$c2023$$dQ1
000131411 594__ $$a7.5$$b2023
000131411 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000131411 700__ $$aGarcía-Mateo, Sandra$$uUniversidad de Zaragoza
000131411 700__ $$aSainz-Arnal, Pilar
000131411 700__ $$aMartínez-García, Javier
000131411 700__ $$aGallego-Llera, Beatriz
000131411 700__ $$aLozano-Limones, María Jesús
000131411 700__ $$aHidalgo, Sandra
000131411 700__ $$0(orcid)0000-0002-3545-2707$$aGargallo-Puyuelo, Carla J.$$uUniversidad de Zaragoza
000131411 700__ $$aLatre-Santos, Marta
000131411 700__ $$aNocito-Colon, Maria Mercedes Lourdes
000131411 700__ $$0(orcid)0000-0003-3043-147X$$aMartínez-Lostao, Luis$$uUniversidad de Zaragoza
000131411 700__ $$aRefaie, Engy
000131411 700__ $$0(orcid)0000-0002-4991-8715$$aArroyo-Villarino, Maria Teresa$$uUniversidad de Zaragoza
000131411 700__ $$adel Rio-Nechaevsky, Marcela
000131411 700__ $$0(orcid)0000-0002-3888-7036$$aRamirez-Labrada, Ariel
000131411 700__ $$aPardo, Julián
000131411 700__ $$0(orcid)0000-0003-0076-3529$$aGomollón, Fernando$$uUniversidad de Zaragoza
000131411 700__ $$0(orcid)0000-0002-8969-7726$$aBaptista, Pedro M.
000131411 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000131411 7102_ $$11011$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Inmunología
000131411 773__ $$g13, 1 (2023), 23061 [11 pp.]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000131411 8564_ $$s2967240$$uhttps://zaguan.unizar.es/record/131411/files/texto_completo.pdf$$yVersión publicada
000131411 8564_ $$s2481974$$uhttps://zaguan.unizar.es/record/131411/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000131411 909CO $$ooai:zaguan.unizar.es:131411$$particulos$$pdriver
000131411 951__ $$a2024-11-22-12:02:09
000131411 980__ $$aARTICLE